The soybean bioactive peptide VHVV alleviates hypertension-induced renal damage in hypertensive rats via the SIRT1-PGC1α/Nrf2 pathway

Bruce Chi Kang Tsai, Wei Wen Kuo, Cecilia Hsuan Day, Dennis Jine Yuan Hsieh, Chia Hua Kuo, Jayasimharayalu Daddam, Ray Jade Chen, V. Vijaya Padma, Guiqing Wang, Chih Yang Huang

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Hypertension triggers oxidative stress, causing dysfunction in organs, including the brain, heart, and kidney. In this study, we examined the potential renal benefit of the soybean bioactive peptide VHVV by in silico analysis and in spontaneously hypertensive rats. Sixteen-week-old spontaneously hypertensive rats were divided into 3 groups and treated with or without VHVV or captopril. Age-matched Wistar-Kyoto rats were used as normotensive control group. The rats were sacrificed after 8 weeks of treatment, and kidneys were analyzed to demonstrate the efficacy of VHVV. In silico analysis confirmed the antihypertensive activity of VHVV. In animal study, VHVV induced antioxidant defense and modulated mitochondrial homeostasis in the hypertensive kidney via SIRT1-PGC1α/Nrf2 pathway. Hence, improvements in renal cells were attributed to the suppression of inflammation and apoptosis, and the architecture of the hypertensive kidney was restored after peptide treatment. Overall, VHVV exhibited therapeutic effects by decreasing renal damage caused by hypertension-induced free radicals.

Original languageEnglish
Article number104255
JournalJournal of Functional Foods
Volume75
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Hypertension
  • Kidney
  • Nrf2
  • PGC1α
  • SIRT1
  • Soybean peptide

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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