The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients

Yu Ting Lin, Chia Hung Yen, Heng Li Chen, Yi Jen Liao, I. Feng Lin, Marcelo Chen, Yu Ching Lan, Shao Yuan Chuang, Shie Liang Hsieh, Yi Ming Arthur Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Purpose: The decoy receptor 3 (DcR3) is a member of the tumor necrosis factor receptor (TNFR) super-family. It counteracts the biological effects of Fas ligands and inhibits apoptosis. The goals of this study were to understand the associations between serologic DcR3 (sDcR3) levels and different human immunodeficiency virus type 1 (HIV-1) subtypes, as well as the AIDS disease progression. Methods: Serum samples from 61 HIV/AIDS patients, who had been followed up every 6 months for 3 years, were collected. sDcR3 levels were quantified using an enzyme immunoassay (EIA). Results: The sDcR3 levels in patients with HIV-1 subtype B were significantly higher than those in patients infected with subtype CRF01_AE (. p

Original languageEnglish
Pages (from-to)498-503
Number of pages6
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume114
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Keywords

  • Decoy receptor 3 (DcR3)
  • Disease progression
  • HIV/AIDS
  • Subtype

ASJC Scopus subject areas

  • Medicine(all)

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