The self and its resting state in consciousness: An investigation of the vegetative state

Zirui Huang, Rui Dai, Xuehai Wu, Zhi Yang, Dongqiang Liu, Jin Hu, Liang Gao, Weijun Tang, Ying Mao, Yi Jin, Xing Wu, Bin Liu, Yao Zhang, Lu Lu, Steven Laureys, Xuchu Weng, Georg Northoff

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Recent studies have demonstrated resting-state abnormalities in midline regions in vegetative state/unresponsive wakefulness syndrome and minimally conscious state patients. However, the functional implications of these resting-state abnormalities remain unclear. Recent findings in healthy subjects have revealed a close overlap between the neural substrate of self-referential processing and the resting-state activity in cortical midline regions. As such, we investigated task-related neural activity during active self-referential processing and various measures of resting-state activity in 11 patients with disorders of consciousness (DOC) and 12 healthy control subjects. Overall, the results revealed that DOC patients exhibited task-specific signal changes in anterior and posterior midline regions, including the perigenual anterior cingulate cortex (PACC) and posterior cingulate cortex (PCC). However, the degree of signal change was significantly lower in DOC patients compared with that in healthy subjects. Moreover, reduced signal differentiation in the PACC predicted the degree of consciousness in DOC patients. Importantly, the same midline regions (PACC and PCC) in DOC patients also exhibited severe abnormalities in the measures of resting-state activity, that is functional connectivity and the amplitude of low-frequency fluctuations. Taken together, our results provide the first evidence of neural abnormalities in both the self-referential processing and the resting state in midline regions in DOC patients. This novel finding has important implications for clinical utility and general understanding of the relationship between the self, the resting state, and consciousness.

Original languageEnglish
Pages (from-to)1997-2008
Number of pages12
JournalHuman Brain Mapping
Volume35
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Persistent Vegetative State
Consciousness Disorders
Consciousness
Gyrus Cinguli
Healthy Volunteers
Wakefulness

Keywords

  • Coma
  • Cortical midline regions
  • Disorders of consciousness
  • FMRI
  • Functional connectivity
  • Low-frequency fluctuations
  • Minimally conscious state
  • Resting state
  • Self-referential processing
  • Vegetative state

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Cite this

The self and its resting state in consciousness : An investigation of the vegetative state. / Huang, Zirui; Dai, Rui; Wu, Xuehai; Yang, Zhi; Liu, Dongqiang; Hu, Jin; Gao, Liang; Tang, Weijun; Mao, Ying; Jin, Yi; Wu, Xing; Liu, Bin; Zhang, Yao; Lu, Lu; Laureys, Steven; Weng, Xuchu; Northoff, Georg.

In: Human Brain Mapping, Vol. 35, No. 5, 2014, p. 1997-2008.

Research output: Contribution to journalArticle

Huang, Z, Dai, R, Wu, X, Yang, Z, Liu, D, Hu, J, Gao, L, Tang, W, Mao, Y, Jin, Y, Wu, X, Liu, B, Zhang, Y, Lu, L, Laureys, S, Weng, X & Northoff, G 2014, 'The self and its resting state in consciousness: An investigation of the vegetative state', Human Brain Mapping, vol. 35, no. 5, pp. 1997-2008. https://doi.org/10.1002/hbm.22308
Huang, Zirui ; Dai, Rui ; Wu, Xuehai ; Yang, Zhi ; Liu, Dongqiang ; Hu, Jin ; Gao, Liang ; Tang, Weijun ; Mao, Ying ; Jin, Yi ; Wu, Xing ; Liu, Bin ; Zhang, Yao ; Lu, Lu ; Laureys, Steven ; Weng, Xuchu ; Northoff, Georg. / The self and its resting state in consciousness : An investigation of the vegetative state. In: Human Brain Mapping. 2014 ; Vol. 35, No. 5. pp. 1997-2008.
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