The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats

Wun-Chang Ko, Joen Rong Sheu, Shu-Huey Tzeng, Chi Ming Chen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T- wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bdph (60 mg/kg, p.o.) did not affect systolic pressure and heart rate in unanesthetized rats. Therefore, Bdph, found in the rhizome of Ligusticum chuaxiong Hort. (L. wallichii Franch., Umbelliferae), appears to have selective antianginal effect without changing blood pressure and heart rate.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalPlanta Medica
Volume64
Issue number3
DOIs
Publication statusPublished - 1998

Keywords

  • Antianginal effects
  • Butylidenephthalide
  • Ligusticum chuaxiong Hort.
  • Ligusticum wallichii Franch.
  • Myocardial ischemia
  • Pituitrin
  • T-wave lowering
  • Umbelliferae

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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