The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men

Marcelo Chen, Yu Chuen Huang, I. ling Ko, Stone Yang, Yen Hwa Chang, William Ji Shian Huang, Yi Ming Arthur Chen

Research output: Contribution to journalArticle

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Abstract

Objectives: To determine the association of a common variant, rs1447295, at the 8q24 region with prostate cancer (PCa) risk in Taiwanese men. Common variants at the 8q24 region have been shown to be associated with PCa risk. The variant rs1447295 has shown the strongest association. Most of the studies have been performed in European and American populations. Methods: This case-control study comprised 340 PCa patients and 337 controls. Genotyping was performed for rs14417295 to test for the association between its risk allele and PCa. Its association with disease stage, Gleason score, PSA level, and disease aggressiveness was also determined. Results: The A allele of rs1447295 was significantly associated with increased PCa risk (odds ratio = 1.49, 95% CI = 1.12-1.99). When compared with controls, the risk allele A was more frequent in PCa patients of both stages I+II (P = .028) and stages III+IV (P = .023), in patients of all Gleason scores (P < .05 in all subgroups), in patients with PSA levels >20 ng/mL (P = .001), and in patients with aggressive disease (P = .005). Conclusions: This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men.

Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalUrology
Volume74
Issue number3
DOIs
Publication statusPublished - Sep 1 2009
Externally publishedYes

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Prostatic Neoplasms
Alleles
Neoplasm Grading
Odds Ratio
Case-Control Studies
Population

ASJC Scopus subject areas

  • Urology

Cite this

Chen, M., Huang, Y. C., Ko, I. L., Yang, S., Chang, Y. H., Huang, W. J. S., & Chen, Y. M. A. (2009). The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men. Urology, 74(3), 698-701. https://doi.org/10.1016/j.urology.2009.02.035

The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men. / Chen, Marcelo; Huang, Yu Chuen; Ko, I. ling; Yang, Stone; Chang, Yen Hwa; Huang, William Ji Shian; Chen, Yi Ming Arthur.

In: Urology, Vol. 74, No. 3, 01.09.2009, p. 698-701.

Research output: Contribution to journalArticle

Chen, M, Huang, YC, Ko, IL, Yang, S, Chang, YH, Huang, WJS & Chen, YMA 2009, 'The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men', Urology, vol. 74, no. 3, pp. 698-701. https://doi.org/10.1016/j.urology.2009.02.035
Chen M, Huang YC, Ko IL, Yang S, Chang YH, Huang WJS et al. The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men. Urology. 2009 Sep 1;74(3):698-701. https://doi.org/10.1016/j.urology.2009.02.035
Chen, Marcelo ; Huang, Yu Chuen ; Ko, I. ling ; Yang, Stone ; Chang, Yen Hwa ; Huang, William Ji Shian ; Chen, Yi Ming Arthur. / The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men. In: Urology. 2009 ; Vol. 74, No. 3. pp. 698-701.
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