The roles of neurotrophins in traumatic brain injury

Ping Hung Lin, Lu Ting Kuo, Hui Tzung Luh

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Neurotrophins are a collection of structurally and functionally related proteins. They play important roles in many aspects of neural development, survival, and plasticity. Traumatic brain injury (TBI) leads to different levels of central nervous tissue destruction and cellular repair through various compensatory mechanisms promoted by the injured brain. Many studies have shown that neurotrophins are key modulators of neuroinflammation, apoptosis, blood–brain barrier permea-bility, memory capacity, and neurite regeneration. The expression of neurotrophins following TBI is affected by the severity of injury, genetic polymorphism, and different post-traumatic time points. Emerging research is focused on the potential therapeutic applications of neurotrophins in manag-ing TBI. We conducted a comprehensive review by organizing the studies that demonstrate the role of neurotrophins in the management of TBI.

Original languageEnglish
Article number26
JournalLife
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Brain-derived neurotrophic factor
  • Nerve growth factor
  • Neurotrophins
  • NT-3
  • NT-4/5
  • Traumatic brain injury

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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