The role of the VEGF-C/VEGFR-3 axis in cancer progression

J. L. Su, C. J. Yen, P. S. Chen, S. E. Chuang, C. C. Hong, I. H. Kuo, H. Y. Chen, M. C. Hung, M. L. Kuo

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171 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.

Original languageEnglish
Pages (from-to)541-545
Number of pages5
JournalBritish Journal of Cancer
Volume96
Issue number4
DOIs
Publication statusPublished - Feb 26 2007
Externally publishedYes

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Keywords

  • Lymphangiogenesis
  • Metastasis
  • VEGF-C
  • VEGFR-3

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Su, J. L., Yen, C. J., Chen, P. S., Chuang, S. E., Hong, C. C., Kuo, I. H., Chen, H. Y., Hung, M. C., & Kuo, M. L. (2007). The role of the VEGF-C/VEGFR-3 axis in cancer progression. British Journal of Cancer, 96(4), 541-545. https://doi.org/10.1038/sj.bjc.6603487