The role of pulmonary inflammation in the development of pulmonary hypertension in newborn with meconium aspiration syndrome (MAS)

Jing M. Wu, Tsu F. Yeh, Jiu Y. Wang, Jieh N. Wang, Yuh J. Lin, Wu S. Hsieh, Chyi H. Lin

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

1. There was no clear correlation between the tracheal aspirate cytokines and the elevation of pulmonary arterial pressure in newborn piglets with MAS. The use of dexamethasone significantly suppressed tracheal aspirate cytokines but did not significantly alter pulmonary arterial pressure. Dexamethasone significantly increased the cardiac stroke volume and blood pressure. 2. Early dexamethasone therapy (< 12 hrs) for one week in infants with MAS significantly improved pulmonary ventilation and facilitated weaning from mechanical ventilation. 3. The mechanisms for the improvement in cardiopulmonary status following early dexamethasone therapy in MAS remain unclear. An overall improvement in cardiac hemodynamics, along with a significant decrease in lung inflammation may be responsible for the improvement. Supported in part by grant NSC 83-0412-B006-080 and NSC 84- 2331-B006-011 from the National Science Council and by grant DOH 84-HR-415 and DOH 85-HR-415 from the National Institute of Health Research, Taiwan, R.O.C.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalPediatric Pulmonology
Volume27
Issue numberSUPPL. 18
DOIs
Publication statusPublished - Mar 31 1999
Externally publishedYes

Fingerprint

Meconium Aspiration Syndrome
Pulmonary Hypertension
Dexamethasone
Pneumonia
Newborn Infant
Organized Financing
Secondary Prevention
Arterial Pressure
Cytokines
Pulmonary Ventilation
Lung
Cardiac Volume
National Institutes of Health (U.S.)
Taiwan
Artificial Respiration
Stroke Volume
Hemodynamics
Blood Pressure
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

The role of pulmonary inflammation in the development of pulmonary hypertension in newborn with meconium aspiration syndrome (MAS). / Wu, Jing M.; Yeh, Tsu F.; Wang, Jiu Y.; Wang, Jieh N.; Lin, Yuh J.; Hsieh, Wu S.; Lin, Chyi H.

In: Pediatric Pulmonology, Vol. 27, No. SUPPL. 18, 31.03.1999, p. 205-208.

Research output: Contribution to journalArticle

Wu, Jing M. ; Yeh, Tsu F. ; Wang, Jiu Y. ; Wang, Jieh N. ; Lin, Yuh J. ; Hsieh, Wu S. ; Lin, Chyi H. / The role of pulmonary inflammation in the development of pulmonary hypertension in newborn with meconium aspiration syndrome (MAS). In: Pediatric Pulmonology. 1999 ; Vol. 27, No. SUPPL. 18. pp. 205-208.
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