The role of procalcitonin for acute pyelonephritis and subsequent renal scarring in infants and young children

Ji Nan Sheu, Hung Ming Chang, Shan Ming Chen, Tung Wei Hung, Ko Huang Lue

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Purpose: We assessed the usefulness of procalcitonin as a biological marker in diagnosing acute pyelonephritis and for predicting subsequent renal scarring in young children with a first febrile urinary tract infection. Materials and Methods: Children 2 years old or younger with a first febrile urinary tract infection were prospectively studied. Renal parenchymal involvement was assessed by 99mTc-dimercaptosuccinic acid scan within 5 days of admission and after 6 months. Serum samples from all patients were tested for procalcitonin, C-reactive protein and white blood cell count measurements. Results: The 112 enrolled patients (age range 24 days to 24 months old) were divided into acute pyelonephritis (76) and lower urinary tract infection (36) groups according to the results of 99mTc-dimercaptosuccinic acid scans. Median values of procalcitonin, C-reactive protein and white blood cell count at hospitalization were significantly higher in patients with acute pyelonephritis than in those with lower urinary tract infection. The area under receiver operating characteristic curves showed that procalcitonin was superior to C-reactive protein and white blood cell count as a marker for diagnosing acute pyelonephritis. Initial and post-antibiotic treatment procalcitonin values were significantly higher in children with renal scarring than in those without scarring (p

Original languageEnglish
Pages (from-to)2002-2008
Number of pages7
JournalJournal of Urology
Volume186
Issue number5
DOIs
Publication statusPublished - Nov 2011
Externally publishedYes

Keywords

  • infant
  • procalcitonin
  • pyelonephritis
  • vesico-ureteral reflux

ASJC Scopus subject areas

  • Urology

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