Abstract

This chapter discusses the role of mitochondria in aging ovary. Human mitochondrial deoxyribonucleic acid (mtDNA) is a maternally inherited double-stranded circular DNA molecule, which is involved in respiratory and oxidative phosphorylation. The human metaphase II oocyte is estimated to have 100,000 mitochondria; however, there is only one mitochondrial genome per organelle. The mtDNA is not protected by histones and is exposed in high concentrations of reactive oxygen species (ROS) and free radicals in the matrix of mitochondria. Thus, the aged oocytes are very vulnerable to oxidative damage and mtDNA mutation. The current study demonstrates that mtDNA 4977bp deletions in compromised human oocytes may range from 56.3% when maternal age is younger than 32 up to 73% when maternal age is older than 37. Most nondisjunction and aneuplodies take place during meiosis, which are highly energy-intensive, and increase exponentially with maternal age. Mitochondria in oocyte and early embryos are structurally immature. They are round or ovoid, with few cristae. They become more elongated with numerous transverse cristae at the blastocyst stage. Nevertheless, after ovulation the multiplication of mitochondria and the replication of mtDNA are not resumed until the gastrulation stage.

Original languageEnglish
Title of host publicationThe Ovary: Second Edition
PublisherElsevier Inc.
Pages569-575
Number of pages7
ISBN (Print)9780080542584, 9780124445628
DOIs
Publication statusPublished - Dec 18 2003

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Ovary
Mitochondria
Oocytes
DNA
Maternal Age
Reactive Oxygen Species
Circular DNA
Gastrulation
Mitochondrial Genome
Oxidative Phosphorylation
Meiosis
Blastocyst
Metaphase
Ovulation
Organelles
Histones
Free Radicals
Embryonic Structures
Mutation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hsieh, R. H., Au, H. K., Wang, R. S., Yang, P. S., & Tzeng, C. R. (2003). The Role of Mitochondria in the Aging Ovary. In The Ovary: Second Edition (pp. 569-575). Elsevier Inc.. https://doi.org/10.1016/B978-012444562-8/50035-5

The Role of Mitochondria in the Aging Ovary. / Hsieh, Rong Hong; Au, Heng Kien; Wang, Ruey Sheng; Yang, Peng Sheng; Tzeng, Chii Ruey.

The Ovary: Second Edition. Elsevier Inc., 2003. p. 569-575.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hsieh, RH, Au, HK, Wang, RS, Yang, PS & Tzeng, CR 2003, The Role of Mitochondria in the Aging Ovary. in The Ovary: Second Edition. Elsevier Inc., pp. 569-575. https://doi.org/10.1016/B978-012444562-8/50035-5
Hsieh RH, Au HK, Wang RS, Yang PS, Tzeng CR. The Role of Mitochondria in the Aging Ovary. In The Ovary: Second Edition. Elsevier Inc. 2003. p. 569-575 https://doi.org/10.1016/B978-012444562-8/50035-5
Hsieh, Rong Hong ; Au, Heng Kien ; Wang, Ruey Sheng ; Yang, Peng Sheng ; Tzeng, Chii Ruey. / The Role of Mitochondria in the Aging Ovary. The Ovary: Second Edition. Elsevier Inc., 2003. pp. 569-575
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