The role of mild hypothermia in air embolism-induced acute lung injury

Chung Kan Peng, Kun Lun Huang, Chin Pyng Wu, Min Hui Li, Hen I. Lin, Ching Wang Hsu, Shih Hung Tsai, Shi Jye Chu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Mild hypothermia has become an important treatment for ischemic brain injury. However, the role of mild hypothermia in air embolism-induced lung injury has not been explored. In this study, we investigated whether treatment with mild hypothermia before and synchronous with air infusion can attenuate acute lung injury induced by air embolism. Methods: In this rat model study (Sprague-Dawley rats), pulmonary air embolism was induced by venous infusion of air at a rate of 25 μL/min for 40 minutes. Control animals received no air infusion. The rats were randomly assigned to 2 control groups of normothermia (37°C) and mild hypothermia (34°C) and 3 air embolism groups of mild hypothermia induced before air infusion, normothermia with air infusion, and mild hypothermia induced synchronous with air infusion. At the end of the experiment, the variables of lung injury were assessed. Results: Air infusion elicited a significant increase in lung wet/dry weight ratio and protein, lactate dehydrogenase, and tumor necrosis factor-α concentration of the bronchoalveolar lavage fluid. Myeloperoxidase activity, neutrophil infiltration, and interstitial edema in lung tissue were also significantly increased. In addition, nuclear factor-κB activity was significantly increased in the lungs. Treatment with mild hypothermia before air infusion reduced increases in these variables, whereas mild hypothermia synchronous with air infusion had no significant effect on them. Conclusions: Our study suggests that mild hypothermia before air infusion decreases air embolism-induced acute lung injury. The protective mechanism seems to be the inhibition of inflammation.

Original languageEnglish
Pages (from-to)1336-1342
Number of pages7
JournalAnesthesia and Analgesia
Volume110
Issue number5
DOIs
Publication statusPublished - May 2010
Externally publishedYes

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Air Embolism
Acute Lung Injury
Hypothermia
Air
Induced Hypothermia
Lung Injury
Lung
Neutrophil Infiltration
Bronchoalveolar Lavage Fluid
Pulmonary Edema
Pulmonary Embolism
L-Lactate Dehydrogenase
Brain Injuries
Peroxidase
Sprague Dawley Rats
Edema
Therapeutics
Tumor Necrosis Factor-alpha
Inflammation
Weights and Measures

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Peng, C. K., Huang, K. L., Wu, C. P., Li, M. H., Lin, H. I., Hsu, C. W., ... Chu, S. J. (2010). The role of mild hypothermia in air embolism-induced acute lung injury. Anesthesia and Analgesia, 110(5), 1336-1342. https://doi.org/10.1213/ANE.0b013e3181d27e90

The role of mild hypothermia in air embolism-induced acute lung injury. / Peng, Chung Kan; Huang, Kun Lun; Wu, Chin Pyng; Li, Min Hui; Lin, Hen I.; Hsu, Ching Wang; Tsai, Shih Hung; Chu, Shi Jye.

In: Anesthesia and Analgesia, Vol. 110, No. 5, 05.2010, p. 1336-1342.

Research output: Contribution to journalArticle

Peng, CK, Huang, KL, Wu, CP, Li, MH, Lin, HI, Hsu, CW, Tsai, SH & Chu, SJ 2010, 'The role of mild hypothermia in air embolism-induced acute lung injury', Anesthesia and Analgesia, vol. 110, no. 5, pp. 1336-1342. https://doi.org/10.1213/ANE.0b013e3181d27e90
Peng, Chung Kan ; Huang, Kun Lun ; Wu, Chin Pyng ; Li, Min Hui ; Lin, Hen I. ; Hsu, Ching Wang ; Tsai, Shih Hung ; Chu, Shi Jye. / The role of mild hypothermia in air embolism-induced acute lung injury. In: Anesthesia and Analgesia. 2010 ; Vol. 110, No. 5. pp. 1336-1342.
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