The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma

Wen Wei Sung, Huei Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The secretion of interleukin-10 by both malignant and immune cells promotes the progression of lung tumors, hence negatively impacting on patient prognosis. As interleukin-10 mediates oncogenic effects through the PI3K/AKT signaling pathway, PI3K/AKT inhibitors might sensitize cancer cells to chemotherapy, thus favoring tumor regression and improving disease outcome.

Original languageEnglish
Article numbere25854
JournalOncoImmunology
Volume2
Issue number9
DOIs
Publication statusPublished - 2013

Keywords

  • CIP2A
  • HPV
  • IL-10
  • IL-10R
  • Lung cancer

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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