The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease

Chong H. Sam, Hsein K. Lu

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Hypochlorous acid (HOCl) has both proinflammatory and anti-inflammatory properties, and seems to play an important role in the immune system. The regulation of normal flora contributes to periodontal health, and HOCI seems to have the ability to attack Gram-negative pathogens during periodontitis. Furthermore, high concentrations of HOCl promote healing by regulating cytokines and growth factors, killing pathogens through chlorination or oxidation, and modulating inflammation through the effects on nuclear factor κB and activator protein-1 of monocytes. After chlo-rination of taurine by HOCl, taurine chloramine is mostly an anti-inflammatory agent and enhances healing. Neither HOCl nor taurine chloramine are common in clinical applications owing to a lack of studies in animal and human models. Both compounds may be suitable as periodontal medication, as they are good antimicrobial agents, inflammation modulators, and healing promoters.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalJournal of Dental Sciences
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Hypochlorous Acid
Periodontal Diseases
Reactive Oxygen Species
Anti-Inflammatory Agents
Inflammation
Periodontitis
Halogenation
Taurine
Transcription Factor AP-1
Anti-Infective Agents
Monocytes
Immune System
Intercellular Signaling Peptides and Proteins
Animal Models
Cytokines
Health
N-chlorotaurine

Keywords

  • Hypochlorous acid
  • NF-κB
  • Periodontitis
  • Taurine chloramine
  • Transcription factor AP-1

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease. / Sam, Chong H.; Lu, Hsein K.

In: Journal of Dental Sciences, Vol. 4, No. 2, 06.2009, p. 45-54.

Research output: Contribution to journalReview article

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