The role of donor characteristics and post-granulocyte colony-stimulating factor white blood cell counts in predicting the adverse events and yields of stem cell mobilization.

Shu Huey Chen, Shang Hsien Yang, Sung Chao Chu, Yu Chieh Su, Chu Yu Chang, Ya Wen Chiu, Ruey Ho Kao, Dian Kun Li, Kuo Liang Yang, Tso Fu Wang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Granulocyte colony-stimulating factor (G-CSF) is now widely used for stem cell mobilization. We evaluated the role of post-G-CSF white blood cell (WBC) counts and donor factors in predicting adverse events and yields associated with mobilization. WBC counts were determined at baseline, after the third and the fifth dose of G-CSF in 476 healthy donors. Donors with WBC ≥ 50 × 10(3)/μL post the third dose of G-CSF experienced more fatigue, myalgia/arthralgia, and chills, but final post-G-CSF CD34(+) cell counts were similar. Although the final CD34(+) cell count was higher in donors with WBC ≥ 50 × 10(3)/μL post the fifth G-CSF, the incidence of side effects was similar. Females more frequently experienced headache, nausea/anorexia, vomiting, fever, and lower final CD34(+) cell count than did males. Donors with body mass index (BMI) ≥ 25 showed higher incidences of sweat and insomnia as well as higher final CD34(+) cell counts. Donor receiving G-CSF ≥ 10 μg/kg tended to experience bone pain, headache and chills more frequently. Multivariate analysis indicated that female gender is an independent factor predictive of the occurrence of most side effects, except for ECOG > 1 and chills. Higher BMI was also an independent predictor for fatigue, myalgia/arthralgia, and sweat. Higher G-CSF dose was associated with bone pain, while the WBC count post the third G-CSF was associated with fatigue only. In addition, one donor in the study period did not complete the mobilization due to suspected anaphylactoid reaction. Observation for 1 h after the first injection of G-CSF is required to prevent complications from unpredictable side effects.

Original languageEnglish
Pages (from-to)652-659
Number of pages8
JournalInternational Journal of Hematology
Volume93
Issue number5
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Hematopoietic Stem Cell Mobilization
Granulocyte Colony-Stimulating Factor
Leukocyte Count
Tissue Donors
Chills
Cell Count
Fatigue
Sweat
Myalgia
Arthralgia
Headache
Body Mass Index
Leukocytes
Bone and Bones
Pain
Incidence
Sleep Initiation and Maintenance Disorders
Anorexia
Blood Donors
Nausea

ASJC Scopus subject areas

  • Hematology

Cite this

The role of donor characteristics and post-granulocyte colony-stimulating factor white blood cell counts in predicting the adverse events and yields of stem cell mobilization. / Chen, Shu Huey; Yang, Shang Hsien; Chu, Sung Chao; Su, Yu Chieh; Chang, Chu Yu; Chiu, Ya Wen; Kao, Ruey Ho; Li, Dian Kun; Yang, Kuo Liang; Wang, Tso Fu.

In: International Journal of Hematology, Vol. 93, No. 5, 2011, p. 652-659.

Research output: Contribution to journalArticle

Chen, Shu Huey ; Yang, Shang Hsien ; Chu, Sung Chao ; Su, Yu Chieh ; Chang, Chu Yu ; Chiu, Ya Wen ; Kao, Ruey Ho ; Li, Dian Kun ; Yang, Kuo Liang ; Wang, Tso Fu. / The role of donor characteristics and post-granulocyte colony-stimulating factor white blood cell counts in predicting the adverse events and yields of stem cell mobilization. In: International Journal of Hematology. 2011 ; Vol. 93, No. 5. pp. 652-659.
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abstract = "Granulocyte colony-stimulating factor (G-CSF) is now widely used for stem cell mobilization. We evaluated the role of post-G-CSF white blood cell (WBC) counts and donor factors in predicting adverse events and yields associated with mobilization. WBC counts were determined at baseline, after the third and the fifth dose of G-CSF in 476 healthy donors. Donors with WBC ≥ 50 × 10(3)/μL post the third dose of G-CSF experienced more fatigue, myalgia/arthralgia, and chills, but final post-G-CSF CD34(+) cell counts were similar. Although the final CD34(+) cell count was higher in donors with WBC ≥ 50 × 10(3)/μL post the fifth G-CSF, the incidence of side effects was similar. Females more frequently experienced headache, nausea/anorexia, vomiting, fever, and lower final CD34(+) cell count than did males. Donors with body mass index (BMI) ≥ 25 showed higher incidences of sweat and insomnia as well as higher final CD34(+) cell counts. Donor receiving G-CSF ≥ 10 μg/kg tended to experience bone pain, headache and chills more frequently. Multivariate analysis indicated that female gender is an independent factor predictive of the occurrence of most side effects, except for ECOG > 1 and chills. Higher BMI was also an independent predictor for fatigue, myalgia/arthralgia, and sweat. Higher G-CSF dose was associated with bone pain, while the WBC count post the third G-CSF was associated with fatigue only. In addition, one donor in the study period did not complete the mobilization due to suspected anaphylactoid reaction. Observation for 1 h after the first injection of G-CSF is required to prevent complications from unpredictable side effects.",
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AU - Chen, Shu Huey

AU - Yang, Shang Hsien

AU - Chu, Sung Chao

AU - Su, Yu Chieh

AU - Chang, Chu Yu

AU - Chiu, Ya Wen

AU - Kao, Ruey Ho

AU - Li, Dian Kun

AU - Yang, Kuo Liang

AU - Wang, Tso Fu

PY - 2011

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