The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells

Medicine & Life Sciences

• Gossypol 100%
• Cyclooxygenase 2 67%
• Dinoprostone 62%
• Colorectal Neoplasms 51%
• HT29 Cells 40%
• Apoptosis 39%
• Tetradecanoylphorbol Acetate 20%
• N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 13%
• Proteins 11%
• Alprostadil 10%
• Cyclooxygenase 2 Inhibitors 10%
• Cell Death 10%
• Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide 8%
• T-Lymphocytes 8%
• Receptors, Prostaglandin E, EP1 Subtype 8%
• Small Interfering RNA 7%
• Colon 7%
• 9-deoxy-delta-9-prostaglandin D2 6%
• bisindolylmaleimide I 6%
• Prostaglandin D2 6%
• Carcinoma 6%
• Dinoprost 5%
• Staurosporine 5%
• Cyclooxygenase Inhibitors 5%
• Protein C Inhibitor 5%
• Diclofenac 5%
• DNA 5%
• Protein Kinase Inhibitors 4%
• Indomethacin 4%
• Protein Kinase C 4%
• Aspirin 4%
• Caspase 3 4%
• Transfection 3%
• Alcohols 3%

Chemical Compounds

• Agent Interacting With Transmitter, Hormone or Drug Receptor 51%
• Gossypol 40%
• Cell Death 29%
• Protein 26%
• Silencing RNA 23%
• Protein Kinase C Inhibitor 14%
• Staurosporine 13%
• Cyclooxygenase 2 Inhibitor 13%
• Apoptosis Induction 13%
• Prostaglandin E2 12%
• Diclofenac 11%
• Apoptotic 10%
• Application 2%