The role of blocking factors and antipaternal lymphocytotoxic antibodies in the success of pregnancy in patients with recurrent spontaneous abortion

J. L. Hwang, H. N. Ho, Y. S. Yang, C. Y. Hsieh, T. Y. Lee, T. J. Gill

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To elucidate the role of mixed lymphocyte reaction blocking factors (BF) and complement-dependent antipaternal lymphocytotoxic antibodies on the outcome of pregnancy in unexplained recurrent spontaneous aborters. Design: A controlled study of immunotherapy in which the treated group was immunized with the husband's or a third party donor's lymphocytes and the control group received autologous lymphocytes. Setting: Tertiary care institution. Patients: Forty-three patients in the control group and 48 patients in the treated group. Intervention: The before and after immunization levels of BF and antipaternal lymphocytotoxic antibodies were measured. Main Outcome Measures: The existence or changing pattern of BF and antipaternal lymphocytotoxic antibodies levels before and after immunization had no influence on the pregnancy outcome in either group of patients. Conclusion: Neither BF nor antipaternal lymphocytotoxic antibodies is essential for successful pregnancy. They probably reflect the immunological response of the mother to exposure to fetal antigens.

Original languageEnglish
Pages (from-to)691-696
Number of pages6
JournalFertility and Sterility
Volume58
Issue number4
Publication statusPublished - Jan 1 1992
Externally publishedYes

Fingerprint

Habitual Abortion
Antilymphocyte Serum
Spontaneous Abortion
Pregnancy
Pregnancy Outcome
Immunization
Lymphocytes
Control Groups
Mixed Lymphocyte Culture Test
Tertiary Healthcare
Spouses
Immunotherapy
Mothers
Outcome Assessment (Health Care)
Tissue Donors
Antigens
blocking factor

Keywords

  • antipaternal lymphocytotoxic antibody
  • blocking factor
  • lymphocyte immunotherapy
  • Recurrent spontaneous abortion

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

The role of blocking factors and antipaternal lymphocytotoxic antibodies in the success of pregnancy in patients with recurrent spontaneous abortion. / Hwang, J. L.; Ho, H. N.; Yang, Y. S.; Hsieh, C. Y.; Lee, T. Y.; Gill, T. J.

In: Fertility and Sterility, Vol. 58, No. 4, 01.01.1992, p. 691-696.

Research output: Contribution to journalArticle

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AU - Lee, T. Y.

AU - Gill, T. J.

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N2 - Objective: To elucidate the role of mixed lymphocyte reaction blocking factors (BF) and complement-dependent antipaternal lymphocytotoxic antibodies on the outcome of pregnancy in unexplained recurrent spontaneous aborters. Design: A controlled study of immunotherapy in which the treated group was immunized with the husband's or a third party donor's lymphocytes and the control group received autologous lymphocytes. Setting: Tertiary care institution. Patients: Forty-three patients in the control group and 48 patients in the treated group. Intervention: The before and after immunization levels of BF and antipaternal lymphocytotoxic antibodies were measured. Main Outcome Measures: The existence or changing pattern of BF and antipaternal lymphocytotoxic antibodies levels before and after immunization had no influence on the pregnancy outcome in either group of patients. Conclusion: Neither BF nor antipaternal lymphocytotoxic antibodies is essential for successful pregnancy. They probably reflect the immunological response of the mother to exposure to fetal antigens.

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