In the age of globalization, infectious diseases can easily cross national boundaries and regional epidemic can easily develop into an international crisis. Therefore, the international community is paying more attention to global health issues than before. Globalization of infectious diseases compels the international community to consider the reasonable and effective governance of public health, and the outdated International Health Regulations (IHR) in 1969 becomes the target of revision. The revised IHR has in many ways fulfilled the need of the international community to deal with the serious public health threats, but it also raised the sovereignty concern in some member states. This article first addresses the relationship between the multilateral agreement and the state sovereignty, and secondly, introduces the impacts of multilateral agreements on global public health and the concern of the member states when the revised IHR enters into force. Finally the paper presents the coping measures of the Taiwanese government.