The resting brain and our self

Self-relatedness modulates resting state neural activity in cortical midline structures

F. Schneider, F. Bermpohl, A. Heinzel, M. Rotte, M. Walter, C. Tempelmann, C. Wiebking, H. Dobrowolny, H. J. Heinze, G. Northoff

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The resting brain shows high neural activity in various regions, the default-mode network, chief among them the cortical midline structures (CMS). The psychological correlate of high resting state neural activity in CMS remains however unclear though speculatively it has been associated with processing of internally-oriented self-relatedness. We used functional MRI to examine internally-oriented self-relatedness during the resting state period. This was indirectly done by letting subjects perceive emotional pictures followed by a fixation cross; the very same pictures were then rated subjectively according to their degree of self-relatedness in a postscanning session. This allowed us to correlate the picture ratings of self-relatedness with signal changes in the subsequent resting state period, i.e. fixation period. The emotional pictures' degree of self-relatedness parametrically modulated subsequent resting state signal changes in various CMS, including ventro- and dorsomedial prefrontal cortex and posterior cingulate cortex. This modulation could be distinguished from effects of emotion dimensions (e.g. valence, intensity) and evoked effects of self-relatedness during the stimulus period itself the latter being observed rather in subcortical regions, e.g. amygdala, ventral striatum, and tectum. In sum, our findings suggest that resting state neural activity in CMS is parametrically and specifically modulated by the preceding stimulus's degree of self-relatedness. This lends further support to the presumed involvement of these regions in processing internally-oriented self-relatedness as distinguished from externally-oriented self-relatedness.

Original languageEnglish
Pages (from-to)120-131
Number of pages12
JournalNeuroscience
Volume157
Issue number1
DOIs
Publication statusPublished - Nov 11 2008

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Gyrus Cinguli
Amygdala
Prefrontal Cortex
Emotions
Magnetic Resonance Imaging
Psychology
Brain
Ventral Striatum

Keywords

  • cortical midline structures
  • fMRI
  • resting state
  • self
  • subcortical

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The resting brain and our self : Self-relatedness modulates resting state neural activity in cortical midline structures. / Schneider, F.; Bermpohl, F.; Heinzel, A.; Rotte, M.; Walter, M.; Tempelmann, C.; Wiebking, C.; Dobrowolny, H.; Heinze, H. J.; Northoff, G.

In: Neuroscience, Vol. 157, No. 1, 11.11.2008, p. 120-131.

Research output: Contribution to journalArticle

Schneider, F, Bermpohl, F, Heinzel, A, Rotte, M, Walter, M, Tempelmann, C, Wiebking, C, Dobrowolny, H, Heinze, HJ & Northoff, G 2008, 'The resting brain and our self: Self-relatedness modulates resting state neural activity in cortical midline structures', Neuroscience, vol. 157, no. 1, pp. 120-131. https://doi.org/10.1016/j.neuroscience.2008.08.014
Schneider, F. ; Bermpohl, F. ; Heinzel, A. ; Rotte, M. ; Walter, M. ; Tempelmann, C. ; Wiebking, C. ; Dobrowolny, H. ; Heinze, H. J. ; Northoff, G. / The resting brain and our self : Self-relatedness modulates resting state neural activity in cortical midline structures. In: Neuroscience. 2008 ; Vol. 157, No. 1. pp. 120-131.
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