The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease: A population based cohort study

Shih Yi Lin, Wei Ming Lin, Cheng Li Lin, Tse Yen Yang, Fung Chang Sung, Yuan Hung Wang, Chia Hung Kao

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.

Original languageEnglish
Pages (from-to)276-280
Number of pages5
JournalEuropean Journal of Internal Medicine
Volume25
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Secondary Hyperparathyroidism
Thyroid Neoplasms
Chronic Kidney Failure
Cohort Studies
Population
Taiwan
Confidence Intervals
Neoplasms
National Health Programs
Proportional Hazards Models
Comorbidity
Retrospective Studies
Databases
Physicians
Research

Keywords

  • End-stage renal disease
  • Hyperparathyroidism
  • Thyroid cancer

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease : A population based cohort study. / Lin, Shih Yi; Lin, Wei Ming; Lin, Cheng Li; Yang, Tse Yen; Sung, Fung Chang; Wang, Yuan Hung; Kao, Chia Hung.

In: European Journal of Internal Medicine, Vol. 25, No. 3, 2014, p. 276-280.

Research output: Contribution to journalArticle

Lin, Shih Yi ; Lin, Wei Ming ; Lin, Cheng Li ; Yang, Tse Yen ; Sung, Fung Chang ; Wang, Yuan Hung ; Kao, Chia Hung. / The relationship between secondary hyperparathyroidism and thyroid cancer in end stage renal disease : A population based cohort study. In: European Journal of Internal Medicine. 2014 ; Vol. 25, No. 3. pp. 276-280.
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N2 - Objectives We conducted a retrospective cohort study to investigate the risk of cancer in end stage renal disease (ESRD) patients with secondary hyperparathyroidism (HPT). Patients and methods This study investigated the elevated overall cancer risk in ESRD patients with secondary HPT in Taiwan. We used a population-based retrospective cohort consisting of original claims data of 1 million beneficiaries randomly sampled from the Taiwan National Health Insurance Research Database (NHIRD). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of cancer in the ESRD with secondary HPT and comparison cohorts, using the Cox proportional hazards regression model. Results We observed that ESRD patients with secondary HPT exhibited a 10.1-fold increased risk of thyroid cancer than did ESRD patients without this parathyroid complication, after adjusting for comorbidities (95% confidence interval = 1.12-91.0). Conclusion These phenomena indicate that ESRD patients with secondary HPT are at greater risk of thyroid cancer. Physicians should be alert for occult thyroid cancer in ESRD patients with secondary HPT.

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