The relationship between psychological factors, inflammation, and nutrition in patients with chronic renal failure undergoing hemodialysis

Liang Jen Wang, Mai Szu Wu, Heng Jung Hsu, I. Wen Wu, Chiao Yin Sun, Chia Chi Chou, Chin Chan Lee, Chi Ren Tsai, Yi Chieh Tsai, Chih Ken Chen

Research output: Contribution to journalArticle

22 Citations (Scopus)


Objective: Hemodialysis has an adverse impact on the immunological, nutritional, and emotional status of patients. The biochemical markers of inflammation and nutrition were studied as well as the relationship of these factors to emotional symptoms. Method: One hundred and ninety-five patients undergoing hemodialysis were enrolled. The mean age was 58.5 years. Emotional symptoms were assessed using the Mini International Neuropsychiatric Interview, Hospital Anxiety and Depression Scale, Chalder Fatigue Scale, and Short-form Health-related Quality of Life. Venus blood was collected for laboratory assessment of serum hemoglobin, albumin, ferritin, C-reactive protein, interleukin (IL) 1β), IL-6, and tumor necrosis factor α. Results: Among the 195 subjects (92 men and 103 women), 47 (24.1%) fulfilled the criteria for a major depressive disorder (MDD). The IL-6 level in patients with a MDD was significantly higher than in the patients without a MDD. Significant correlation was observed among the following factors: IL-6, fatigue, and quality of life for both physical and mental components. The albumin levels showed a significant correlation with the IL-6 and depression scores. Conclusions: These results show that the serum levels of albumin and IL-6 might be laboratory markers associated with the expression of emotional symptoms in patients undergoing hemodialysis. Prospective studies are needed to determine the causal relationships among these variables.

Original languageEnglish
Pages (from-to)105-118
Number of pages14
JournalInternational Journal of Psychiatry in Medicine
Issue number2
Publication statusPublished - Jan 1 2012
Externally publishedYes



  • Albumin
  • Cytokine
  • Emotion
  • Renal disease
  • Structural equation modeling

ASJC Scopus subject areas

  • Psychiatry and Mental health

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