Abstract

Objective: Paternal characteristics have never been considered in the relation between maternal schizophrenia and adverse pregnancy outcomes. The aim of our study was to consider different paternal ages while investigating the relation between maternal schizophrenia and low birth weight (LBW), using a nationwide population-based dataset. Method: Our study used data from the 2001 to 2003 Taiwan National Health Insurance Research Dataset and birth certificate registry. A total of 543 394 singleton live births were included. We performed multivariate logistic regression analyses to explore the relation between maternal schizophrenia and the risk of LBW, taking different paternal age groups into account (aged 29 years or younger, 30 to 39 years, and 40 years and older), and after adjusting for other characteristics of infant, mother, and father as well as the difference between the parent's ages. Results: Mothers with schizophrenia had a higher percentage of LBW infants than mothers who did not (11.8%, compared with 6.8%). For infants whose mothers had schizophrenia, the adjusted odds ratios of LBW were 1.47 (95% CI 1.02 to 2.27, P <0.05) and 2.80 (95% CI 1.42 to 5.51, P <0.01) times greater than for infants whose mothers did not have schizophrenia, for paternal age groups of 30 to 39 years and 40 years or older, respectively. However, maternal schizophrenia was not a significant predictor ofLBW for infants whose fathers were aged 29 years and younger. Conclusions: The relation between LBW and maternal schizophrenia is modified by paternal age. More attention should be paid to the interaction of paternal characteristics and maternal psychiatric disorders in producing adverse pregnancy outcomes.

Original languageEnglish
Pages (from-to)377-385
Number of pages9
JournalCanadian Journal of Psychiatry
Volume55
Issue number6
Publication statusPublished - 2010

Fingerprint

Paternal Age
Low Birth Weight Infant
Schizophrenia
Mothers
Pregnancy Outcome
Fathers
Age Groups
Birth Certificates
National Health Programs
Live Birth
Taiwan
Psychiatry
Registries

Keywords

  • Parental schizophrenia
  • Paternal schizophrenia
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Medicine(all)

Cite this

@article{256582f3e6cf444dba684b40ecbb85f7,
title = "The relation between maternal schizophrenia and low birth weight is modified by paternal age",
abstract = "Objective: Paternal characteristics have never been considered in the relation between maternal schizophrenia and adverse pregnancy outcomes. The aim of our study was to consider different paternal ages while investigating the relation between maternal schizophrenia and low birth weight (LBW), using a nationwide population-based dataset. Method: Our study used data from the 2001 to 2003 Taiwan National Health Insurance Research Dataset and birth certificate registry. A total of 543 394 singleton live births were included. We performed multivariate logistic regression analyses to explore the relation between maternal schizophrenia and the risk of LBW, taking different paternal age groups into account (aged 29 years or younger, 30 to 39 years, and 40 years and older), and after adjusting for other characteristics of infant, mother, and father as well as the difference between the parent's ages. Results: Mothers with schizophrenia had a higher percentage of LBW infants than mothers who did not (11.8{\%}, compared with 6.8{\%}). For infants whose mothers had schizophrenia, the adjusted odds ratios of LBW were 1.47 (95{\%} CI 1.02 to 2.27, P <0.05) and 2.80 (95{\%} CI 1.42 to 5.51, P <0.01) times greater than for infants whose mothers did not have schizophrenia, for paternal age groups of 30 to 39 years and 40 years or older, respectively. However, maternal schizophrenia was not a significant predictor ofLBW for infants whose fathers were aged 29 years and younger. Conclusions: The relation between LBW and maternal schizophrenia is modified by paternal age. More attention should be paid to the interaction of paternal characteristics and maternal psychiatric disorders in producing adverse pregnancy outcomes.",
keywords = "Parental schizophrenia, Paternal schizophrenia, Schizophrenia",
author = "Lin, {Herng Ching} and Lee, {Hsin Chien} and Tang, {Chao Hsiun} and Chen, {Yi Hua}",
year = "2010",
language = "English",
volume = "55",
pages = "377--385",
journal = "Canadian Journal of Psychiatry",
issn = "0706-7437",
publisher = "Canadian Psychiatric Association",
number = "6",

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T1 - The relation between maternal schizophrenia and low birth weight is modified by paternal age

AU - Lin, Herng Ching

AU - Lee, Hsin Chien

AU - Tang, Chao Hsiun

AU - Chen, Yi Hua

PY - 2010

Y1 - 2010

N2 - Objective: Paternal characteristics have never been considered in the relation between maternal schizophrenia and adverse pregnancy outcomes. The aim of our study was to consider different paternal ages while investigating the relation between maternal schizophrenia and low birth weight (LBW), using a nationwide population-based dataset. Method: Our study used data from the 2001 to 2003 Taiwan National Health Insurance Research Dataset and birth certificate registry. A total of 543 394 singleton live births were included. We performed multivariate logistic regression analyses to explore the relation between maternal schizophrenia and the risk of LBW, taking different paternal age groups into account (aged 29 years or younger, 30 to 39 years, and 40 years and older), and after adjusting for other characteristics of infant, mother, and father as well as the difference between the parent's ages. Results: Mothers with schizophrenia had a higher percentage of LBW infants than mothers who did not (11.8%, compared with 6.8%). For infants whose mothers had schizophrenia, the adjusted odds ratios of LBW were 1.47 (95% CI 1.02 to 2.27, P <0.05) and 2.80 (95% CI 1.42 to 5.51, P <0.01) times greater than for infants whose mothers did not have schizophrenia, for paternal age groups of 30 to 39 years and 40 years or older, respectively. However, maternal schizophrenia was not a significant predictor ofLBW for infants whose fathers were aged 29 years and younger. Conclusions: The relation between LBW and maternal schizophrenia is modified by paternal age. More attention should be paid to the interaction of paternal characteristics and maternal psychiatric disorders in producing adverse pregnancy outcomes.

AB - Objective: Paternal characteristics have never been considered in the relation between maternal schizophrenia and adverse pregnancy outcomes. The aim of our study was to consider different paternal ages while investigating the relation between maternal schizophrenia and low birth weight (LBW), using a nationwide population-based dataset. Method: Our study used data from the 2001 to 2003 Taiwan National Health Insurance Research Dataset and birth certificate registry. A total of 543 394 singleton live births were included. We performed multivariate logistic regression analyses to explore the relation between maternal schizophrenia and the risk of LBW, taking different paternal age groups into account (aged 29 years or younger, 30 to 39 years, and 40 years and older), and after adjusting for other characteristics of infant, mother, and father as well as the difference between the parent's ages. Results: Mothers with schizophrenia had a higher percentage of LBW infants than mothers who did not (11.8%, compared with 6.8%). For infants whose mothers had schizophrenia, the adjusted odds ratios of LBW were 1.47 (95% CI 1.02 to 2.27, P <0.05) and 2.80 (95% CI 1.42 to 5.51, P <0.01) times greater than for infants whose mothers did not have schizophrenia, for paternal age groups of 30 to 39 years and 40 years or older, respectively. However, maternal schizophrenia was not a significant predictor ofLBW for infants whose fathers were aged 29 years and younger. Conclusions: The relation between LBW and maternal schizophrenia is modified by paternal age. More attention should be paid to the interaction of paternal characteristics and maternal psychiatric disorders in producing adverse pregnancy outcomes.

KW - Parental schizophrenia

KW - Paternal schizophrenia

KW - Schizophrenia

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