Background: High-sensitivity C-reactive protein (hsCRP) is a key risk factor in coronary artery disease (CAD) in women; however, previous studies yielded inconsistent results regarding the influencing factors that affect women. Purpose：The purpose of this study was to explore the related factors of hsCRP in middle-aged women who were suspected of having CAD. Methods：This was a cross-sectional study, and 128 middle-aged women who were suspected of having CAD and were waiting for catheterization were recruited. Blood was collected to conduct analyses during catheterization procedures. Patients were divided into 2 groups based on their hsCRP blood levels (≤ 3or ＞ 3 mg/L). Data were collected from completed questionnaires, medical records, and blood test results. Results: Overall, the average age was 56.9±5.7 years, and 23 (18%) exhibited an hsCRP level of ＞ 3 mg/L. Patients who were classified into the hsCRP level of ＞ 3 mg/L group had a history of renal insufficiency, had used diuretics, possessed a high number of stenotic blood vessels, and were physically inactive. After controlling confounding factors, physical inactivity was a significant predictor to the hsCRP level. Patients who were physical inactivity possessed a 3.8-fold higher probability of exhibiting higher hsCRP levels than patients who were active (P = 0.01). Conclusions：Physical inactivity was significantly correlated with high hsCRP levels. Middle-aged women should maintain physical activity to reduce inflammatory reactions, thereby reducing the risk of CAD.
- High sensitivity C-reactive protein
- Middle aged
- Physical activity