The ratio of AGE to sRAGE independently associated with albuminuria in hypertensive patients

Kuang Hsing Chiang, Jaw Wen Chen, Shao Sung Huang, Hsin Bang Leu, Shing Jong Lin, Po Hsun Huang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Soluble receptor for advanced glycation end-products (sRAGE) and advanced glycation end-products (AGE) have been associated with risks of cardiovascular disease. Because sRAGE is regarded as a scavenger to AGE, we hypothesized that the ratio of AGE to sRAGE (AGE/sRAGE) is associated with albuminuria in hypertensive patients. Methods: In this cross-sectional study, a total of 104 patients with essential hypertension were recruited. Hypertension was defined as a systolic blood pressure ≥ 140 mmHg, a diastolic blood pressure ≥ 90 mmHg, or use of antihypertensive treatment. Albuminuria was defined as albumin excretion rate 20 μg/min. Multivariate logistic regression analyses were performed to evaluate the association between AGE/sRAGE and albuminuria. Results: Among the 104 patients, 30 (28.8%) patients had albuminuria and 74 (71.2%) patients did not. Patients with albuminuria had higher AGE (2.15 vs. 1.71 μg/mL), lower sRAGE (424.5 vs. 492.5 pg/ml) and higher AGE/sRAGE (3.79 vs. 3.29 μg/pg) than those without albuminuria. Multivariate logistic regression model revealed that AGE/sRAGE (OR = 1.131, 95% CI = 1.001-1.278, P = 0.048) was independently associated with albuminuria. There was no significant relationship between AGE and sRAGE alone with albuminuria. Conclusion: This study suggests that the ratio of AGE to sRAGE may be a surrogate biomarker for microvascular injury. Further prospective studies of the prognostic value of the ratio in relation to microvasular injury are needed.

Original languageEnglish
Article number84
JournalBMC Endocrine Disorders
Volume18
Issue number1
DOIs
Publication statusPublished - Nov 13 2018

Keywords

  • Advanced glycosylation end product-specific receptor
  • Advanced glycosylation end products
  • Albuminuria
  • Hypertension

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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