The quantitative detection of aripiprazole and its main metabolite by using capillary-electrophoresis

Chia Jui Tsai; Yen Hsin Yu; Hsien Jane Chiu; El Wui Loh; Jau Tay Wang; Chin Hong Chan; Tsuo Hung Lan

doi:10.1016/j.jcma.2011.04.006

The quantitative detection of aripiprazole and its main metabolite by using capillary-electrophoresis

Chia Jui Tsai, Yen Hsin Yu, Hsien Jane Chiu, El Wui Loh, Jau Tay Wang, Chin Hong Chan, Tsuo Hung Lan

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: We aimed to establish a feasible and reliable method to measure the level of aripiprazole and its main metabolite, dehydroaripiprazole, using a capillary-electrophoresis (CE) machine. Methods: Two blood samples were obtained from psychiatric patients hospitalized in Yu-Li Hospital who had been treated with aripiprazole for more than 4 weeks, at least 10 mg/d. Conditions for voltage, temperature and buffer concentration was optimized on a CE machine. Results: The most optimal conditions for CE were 80 mM 2-3% DMSO-phosphate as a buffer under pH = 3.0, 15 KV, 20°C and a detection wavelength of 214 nm. The linear ranges of aripiprazole and dehydroaripiprazole concentration were from 0.5 to 50 ng/mL. Conclusion: CE method is a feasible method to measure aripiprazole level with relatively low price compared with other analytical techniques for clinical use.

Original language	English
Pages (from-to)	267-271
Number of pages	5
Journal	Journal of the Chinese Medical Association
Volume	74
Issue number	6
DOIs	https://doi.org/10.1016/j.jcma.2011.04.006
Publication status	Published - Jun 1 2011
Externally published	Yes

Keywords

Aripiprazole
Capillary-electrophoresis
Dehydroaripiprazole
Detection

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.jcma.2011.04.006

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title = "The quantitative detection of aripiprazole and its main metabolite by using capillary-electrophoresis",

abstract = "Background: We aimed to establish a feasible and reliable method to measure the level of aripiprazole and its main metabolite, dehydroaripiprazole, using a capillary-electrophoresis (CE) machine. Methods: Two blood samples were obtained from psychiatric patients hospitalized in Yu-Li Hospital who had been treated with aripiprazole for more than 4 weeks, at least 10 mg/d. Conditions for voltage, temperature and buffer concentration was optimized on a CE machine. Results: The most optimal conditions for CE were 80 mM 2-3% DMSO-phosphate as a buffer under pH = 3.0, 15 KV, 20°C and a detection wavelength of 214 nm. The linear ranges of aripiprazole and dehydroaripiprazole concentration were from 0.5 to 50 ng/mL. Conclusion: CE method is a feasible method to measure aripiprazole level with relatively low price compared with other analytical techniques for clinical use.",

keywords = "Aripiprazole, Capillary-electrophoresis, Dehydroaripiprazole, Detection",

author = "Tsai, {Chia Jui} and Yu, {Yen Hsin} and Chiu, {Hsien Jane} and Loh, {El Wui} and Wang, {Jau Tay} and Chan, {Chin Hong} and Lan, {Tsuo Hung}",

year = "2011",

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doi = "10.1016/j.jcma.2011.04.006",

language = "English",

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journal = "Journal of the Chinese Medical Association",

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T1 - The quantitative detection of aripiprazole and its main metabolite by using capillary-electrophoresis

AU - Tsai, Chia Jui

AU - Yu, Yen Hsin

AU - Chiu, Hsien Jane

AU - Loh, El Wui

AU - Wang, Jau Tay

AU - Chan, Chin Hong

AU - Lan, Tsuo Hung

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Background: We aimed to establish a feasible and reliable method to measure the level of aripiprazole and its main metabolite, dehydroaripiprazole, using a capillary-electrophoresis (CE) machine. Methods: Two blood samples were obtained from psychiatric patients hospitalized in Yu-Li Hospital who had been treated with aripiprazole for more than 4 weeks, at least 10 mg/d. Conditions for voltage, temperature and buffer concentration was optimized on a CE machine. Results: The most optimal conditions for CE were 80 mM 2-3% DMSO-phosphate as a buffer under pH = 3.0, 15 KV, 20°C and a detection wavelength of 214 nm. The linear ranges of aripiprazole and dehydroaripiprazole concentration were from 0.5 to 50 ng/mL. Conclusion: CE method is a feasible method to measure aripiprazole level with relatively low price compared with other analytical techniques for clinical use.

AB - Background: We aimed to establish a feasible and reliable method to measure the level of aripiprazole and its main metabolite, dehydroaripiprazole, using a capillary-electrophoresis (CE) machine. Methods: Two blood samples were obtained from psychiatric patients hospitalized in Yu-Li Hospital who had been treated with aripiprazole for more than 4 weeks, at least 10 mg/d. Conditions for voltage, temperature and buffer concentration was optimized on a CE machine. Results: The most optimal conditions for CE were 80 mM 2-3% DMSO-phosphate as a buffer under pH = 3.0, 15 KV, 20°C and a detection wavelength of 214 nm. The linear ranges of aripiprazole and dehydroaripiprazole concentration were from 0.5 to 50 ng/mL. Conclusion: CE method is a feasible method to measure aripiprazole level with relatively low price compared with other analytical techniques for clinical use.

KW - Aripiprazole

KW - Capillary-electrophoresis

KW - Dehydroaripiprazole

KW - Detection

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The quantitative detection of aripiprazole and its main metabolite by using capillary-electrophoresis

Abstract

Keywords

ASJC Scopus subject areas

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