The quantitative detection of aripiprazole and its main metabolite by using capillary-electrophoresis

Chia Jui Tsai, Yen Hsin Yu, Hsien Jane Chiu, El Wui Loh, Jau Tay Wang, Chin Hong Chan, Tsuo Hung Lan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: We aimed to establish a feasible and reliable method to measure the level of aripiprazole and its main metabolite, dehydroaripiprazole, using a capillary-electrophoresis (CE) machine. Methods: Two blood samples were obtained from psychiatric patients hospitalized in Yu-Li Hospital who had been treated with aripiprazole for more than 4 weeks, at least 10 mg/d. Conditions for voltage, temperature and buffer concentration was optimized on a CE machine. Results: The most optimal conditions for CE were 80 mM 2-3% DMSO-phosphate as a buffer under pH = 3.0, 15 KV, 20°C and a detection wavelength of 214 nm. The linear ranges of aripiprazole and dehydroaripiprazole concentration were from 0.5 to 50 ng/mL. Conclusion: CE method is a feasible method to measure aripiprazole level with relatively low price compared with other analytical techniques for clinical use.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalJournal of the Chinese Medical Association
Volume74
Issue number6
DOIs
Publication statusPublished - Jun 1 2011
Externally publishedYes

Keywords

  • Aripiprazole
  • Capillary-electrophoresis
  • Dehydroaripiprazole
  • Detection

ASJC Scopus subject areas

  • Medicine(all)

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