Abstract

In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of α-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCI4) intoxication in mice. Moreover, PMC significantly improved the CCI4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCI4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo.

Original languageEnglish
Pages (from-to)1271-1276
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume24
Issue number11
DOIs
Publication statusPublished - 2001

Keywords

  • 2,2,5,7,8-pentamethyl-6-hydroxychromane
  • Antioxidant
  • Carbon tetrachloride
  • Hepatotoxicity

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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