Abstract

In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of α-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCI4) intoxication in mice. Moreover, PMC significantly improved the CCI4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCI4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo.

Original languageEnglish
Pages (from-to)1271-1276
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume24
Issue number11
DOIs
Publication statusPublished - 2001

Fingerprint

Carbon Tetrachloride
Liver
Tocopherols
Glutathione Reductase
Glutathione Peroxidase
Aspartate Aminotransferases
Alanine Transaminase
Superoxide Dismutase
Glutathione
Lipids
Wounds and Injuries

Keywords

  • 2,2,5,7,8-pentamethyl-6-hydroxychromane
  • Antioxidant
  • Carbon tetrachloride
  • Hepatotoxicity

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "The protective effects of PMC against chronic carbon tetrachloride-induced hepatotocity in vivo",
abstract = "In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of α-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCI4) intoxication in mice. Moreover, PMC significantly improved the CCI4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCI4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo.",
keywords = "2,2,5,7,8-pentamethyl-6-hydroxychromane, Antioxidant, Carbon tetrachloride, Hepatotoxicity",
author = "George Hsiao and Lin, {Yun H.} and Chien-Huang Lin and Chou, {Duen Suey} and Lin, {Wen Chun} and Sheu, {Joen Rong}",
year = "2001",
doi = "10.1248/bpb.24.1271",
language = "English",
volume = "24",
pages = "1271--1276",
journal = "Biological and Pharmaceutical Bulletin",
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T1 - The protective effects of PMC against chronic carbon tetrachloride-induced hepatotocity in vivo

AU - Hsiao, George

AU - Lin, Yun H.

AU - Lin, Chien-Huang

AU - Chou, Duen Suey

AU - Lin, Wen Chun

AU - Sheu, Joen Rong

PY - 2001

Y1 - 2001

N2 - In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of α-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCI4) intoxication in mice. Moreover, PMC significantly improved the CCI4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCI4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo.

AB - In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of α-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCI4) intoxication in mice. Moreover, PMC significantly improved the CCI4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCI4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo.

KW - 2,2,5,7,8-pentamethyl-6-hydroxychromane

KW - Antioxidant

KW - Carbon tetrachloride

KW - Hepatotoxicity

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