The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells

Gow Chin Yen; Hsing Chang Chiang; Chi Hao Wu; Chi Tai Yeh

doi:10.1016/S0278-6915(03)00174-1

The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells

Gow Chin Yen, Hsing Chang Chiang, Chi Hao Wu, Chi Tai Yeh

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The protective effects of 3,3″-di-OH-terphenyllin (3,3″-DHT) and 3-OH-terphenyllin (3-HT), two secondary metabolites produced by Aspergillus candidus (CCRC31543), against hydrogen peroxide-induced oxidative damage to Int 407 cells, were evaluated. The results showed that H ₂O ₂ caused an increase in lactate dehydrogenase (LDH) leakage and DNA damage in Int 407 cells; however, the addition of 3,3″-DHT and 3-HT significantly reduced this effect (P0.05), but oxidized glutathione levels increased when Int 407 cells were pre-incubated with these two compounds. These findings suggest that 3,3″-DHT and 3-HT have the ability to protect against oxidative damage to Int 407 cells and that this protective effect may be associated with the ability to reduce ROS formation and increase catalase activity.

Original language	English
Pages (from-to)	1561-1567
Number of pages	7
Journal	Food and Chemical Toxicology
Volume	41
Issue number	11
DOIs	https://doi.org/10.1016/S0278-6915(03)00174-1
Publication status	Published - Nov 1 2003
Externally published	Yes

Keywords

3,3″-Dihydroxyterphenyllin
3-Hydroxyterphenyllin
Aspergillus candidus
Int 407 cells
Oxidative damage

ASJC Scopus subject areas

Food Science
Toxicology

Access to Document

10.1016/S0278-6915(03)00174-1

Cite this

@article{35ffb66a46944a6eafef7a4716c9daf7,

title = "The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells",

abstract = "The protective effects of 3,3″-di-OH-terphenyllin (3,3″-DHT) and 3-OH-terphenyllin (3-HT), two secondary metabolites produced by Aspergillus candidus (CCRC31543), against hydrogen peroxide-induced oxidative damage to Int 407 cells, were evaluated. The results showed that H 2O 2 caused an increase in lactate dehydrogenase (LDH) leakage and DNA damage in Int 407 cells; however, the addition of 3,3″-DHT and 3-HT significantly reduced this effect (P0.05), but oxidized glutathione levels increased when Int 407 cells were pre-incubated with these two compounds. These findings suggest that 3,3″-DHT and 3-HT have the ability to protect against oxidative damage to Int 407 cells and that this protective effect may be associated with the ability to reduce ROS formation and increase catalase activity.",

keywords = "3,3″-Dihydroxyterphenyllin, 3-Hydroxyterphenyllin, Aspergillus candidus, Int 407 cells, Oxidative damage",

author = "Yen, {Gow Chin} and Chiang, {Hsing Chang} and Wu, {Chi Hao} and Yeh, {Chi Tai}",

year = "2003",

month = nov,

day = "1",

doi = "10.1016/S0278-6915(03)00174-1",

language = "English",

volume = "41",

pages = "1561--1567",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Limited",

number = "11",

}

TY - JOUR

T1 - The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells

AU - Yen, Gow Chin

AU - Chiang, Hsing Chang

AU - Wu, Chi Hao

AU - Yeh, Chi Tai

PY - 2003/11/1

Y1 - 2003/11/1

N2 - The protective effects of 3,3″-di-OH-terphenyllin (3,3″-DHT) and 3-OH-terphenyllin (3-HT), two secondary metabolites produced by Aspergillus candidus (CCRC31543), against hydrogen peroxide-induced oxidative damage to Int 407 cells, were evaluated. The results showed that H 2O 2 caused an increase in lactate dehydrogenase (LDH) leakage and DNA damage in Int 407 cells; however, the addition of 3,3″-DHT and 3-HT significantly reduced this effect (P0.05), but oxidized glutathione levels increased when Int 407 cells were pre-incubated with these two compounds. These findings suggest that 3,3″-DHT and 3-HT have the ability to protect against oxidative damage to Int 407 cells and that this protective effect may be associated with the ability to reduce ROS formation and increase catalase activity.

AB - The protective effects of 3,3″-di-OH-terphenyllin (3,3″-DHT) and 3-OH-terphenyllin (3-HT), two secondary metabolites produced by Aspergillus candidus (CCRC31543), against hydrogen peroxide-induced oxidative damage to Int 407 cells, were evaluated. The results showed that H 2O 2 caused an increase in lactate dehydrogenase (LDH) leakage and DNA damage in Int 407 cells; however, the addition of 3,3″-DHT and 3-HT significantly reduced this effect (P0.05), but oxidized glutathione levels increased when Int 407 cells were pre-incubated with these two compounds. These findings suggest that 3,3″-DHT and 3-HT have the ability to protect against oxidative damage to Int 407 cells and that this protective effect may be associated with the ability to reduce ROS formation and increase catalase activity.

KW - 3,3″-Dihydroxyterphenyllin

KW - 3-Hydroxyterphenyllin

KW - Aspergillus candidus

KW - Int 407 cells

KW - Oxidative damage

UR - http://www.scopus.com/inward/record.url?scp=0041378224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041378224&partnerID=8YFLogxK

U2 - 10.1016/S0278-6915(03)00174-1

DO - 10.1016/S0278-6915(03)00174-1

M3 - Article

C2 - 12963009

AN - SCOPUS:0041378224

SN - 0278-6915

VL - 41

SP - 1561

EP - 1567

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

IS - 11

ER -

The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this