The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells

Gow Chin Yen, Hsing Chang Chiang, Chi Hao Wu, Chi Tai Yeh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The protective effects of 3,3″-di-OH-terphenyllin (3,3″-DHT) and 3-OH-terphenyllin (3-HT), two secondary metabolites produced by Aspergillus candidus (CCRC31543), against hydrogen peroxide-induced oxidative damage to Int 407 cells, were evaluated. The results showed that H 2O 2 caused an increase in lactate dehydrogenase (LDH) leakage and DNA damage in Int 407 cells; however, the addition of 3,3″-DHT and 3-HT significantly reduced this effect (P0.05), but oxidized glutathione levels increased when Int 407 cells were pre-incubated with these two compounds. These findings suggest that 3,3″-DHT and 3-HT have the ability to protect against oxidative damage to Int 407 cells and that this protective effect may be associated with the ability to reduce ROS formation and increase catalase activity.

Original languageEnglish
Pages (from-to)1561-1567
Number of pages7
JournalFood and Chemical Toxicology
Volume41
Issue number11
DOIs
Publication statusPublished - Nov 1 2003
Externally publishedYes

Fingerprint

Aspergillus candidus
Aspergillus
Metabolites
Hydrogen Peroxide
protective effect
hydrogen peroxide
metabolites
cells
lactate dehydrogenase
DNA damage
secondary metabolites
glutathione
catalase
Glutathione Disulfide
L-Lactate Dehydrogenase
Catalase
DNA Damage
hydroxide ion
3-hydroxyterphenyllin
DNA

Keywords

  • 3,3″-Dihydroxyterphenyllin
  • 3-Hydroxyterphenyllin
  • Aspergillus candidus
  • Int 407 cells
  • Oxidative damage

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells. / Yen, Gow Chin; Chiang, Hsing Chang; Wu, Chi Hao; Yeh, Chi Tai.

In: Food and Chemical Toxicology, Vol. 41, No. 11, 01.11.2003, p. 1561-1567.

Research output: Contribution to journalArticle

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