The protective effect of hypervolemic hemodilution in experimental heatstroke

Chen Kuei Chang, Cheu Heng Chien, Hung Li Chou, Mao Tsun Lin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The authors tested the hypothesis in a rat model that hypervolemic hemodilution during heatstroke affected the mean arterial pressure (MAP), striatal dopamine (DA) release, and local cerebral blood flow and neuronal damage score in different brain structures. The heatstroke was induced by exposing the urethane-anesthetized rats to an ambient temperature of 42°C. Hypervolemic hemodilution was produced by intravenous administration of 10% human albumin. Relative and absolute blood flow in the corpus striatum were determined using the laser Doppler flowmetry and the autoradiography diffusible tracer technique, respectively. The DA release in the striatum was estimated using the in vivo microdialysis technique. After onset of heatstroke, animals with hypervolemic state alone, produced by saline or heparinized blood injection, displayed higher values of DA release, as well as neuronal damage score in the striatum, hypothalamus, or cortex, but lower values of MAP and blood flow in the striatum, hypothalamus, or cortex compared to normothermic controls. However, the heatstroke-induced arterial hypotension, cerebral ischemia, increased striatal DA overload, and increased neuronal damage score were attenuated by induction of both hypervolemic and hemodilution state with 10% albumin either before or after the onset of heatstroke. In addition, constant infusions of a vasopressor agent phenylephrine (2 μg kg-1 min-1) after the onset of heatstroke failed to maintain appropriate levels of MAP and resulted in no protection against heatstroke. Thus, it appears that the observed benefit of the 10% albumin is secondary to hemodilution and/or maintenance of MAP.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalShock
Volume16
Issue number2
Publication statusPublished - Aug 2001
Externally publishedYes

Fingerprint

Heat Stroke
Hemodilution
Corpus Striatum
Dopamine
Arterial Pressure
Albumins
Hypothalamus
Cerebrovascular Circulation
Controlled Hypotension
Laser-Doppler Flowmetry
Urethane
Microdialysis
Phenylephrine
Vasoconstrictor Agents
Brain Ischemia
Autoradiography
Intravenous Administration
Maintenance
Injections
Temperature

Keywords

  • Arterial hypotension
  • Cerebral ischemia
  • Heatstroke
  • Hypervolemic hemodilution
  • Neuronal damage

ASJC Scopus subject areas

  • Physiology
  • Critical Care and Intensive Care Medicine

Cite this

Chang, C. K., Chien, C. H., Chou, H. L., & Lin, M. T. (2001). The protective effect of hypervolemic hemodilution in experimental heatstroke. Shock, 16(2), 153-158.

The protective effect of hypervolemic hemodilution in experimental heatstroke. / Chang, Chen Kuei; Chien, Cheu Heng; Chou, Hung Li; Lin, Mao Tsun.

In: Shock, Vol. 16, No. 2, 08.2001, p. 153-158.

Research output: Contribution to journalArticle

Chang, CK, Chien, CH, Chou, HL & Lin, MT 2001, 'The protective effect of hypervolemic hemodilution in experimental heatstroke', Shock, vol. 16, no. 2, pp. 153-158.
Chang, Chen Kuei ; Chien, Cheu Heng ; Chou, Hung Li ; Lin, Mao Tsun. / The protective effect of hypervolemic hemodilution in experimental heatstroke. In: Shock. 2001 ; Vol. 16, No. 2. pp. 153-158.
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