The protective effect of curcumin on ischemia-reperfusion-induced liver injury

C. M. Lin, J. F. Lee, L. L. Chiang, C. F. Chen, D. Wang, Chien-Ling Su

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. Materials and Methods: Ischemia was induced by clamping the common hepatic artery and portal vein of rats for 30 minutes. Thereafter, flow was restored and the liver was reperfused for 80 minutes. Blood samples collected prior to ischemia and after reperfusion were analyzed for methyl guanidine (MG), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and adenosphate triphosphate (ATP). Blood levels of serum glutamic oxaloacetic transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT), and lactic dehydrogenase (LDH), which served as indexes of liver injury, were measured. Results: The protocol resulted in elevation of blood NO (P

Original languageEnglish
Pages (from-to)974-977
Number of pages4
JournalTransplantation Proceedings
Volume44
Issue number4
DOIs
Publication statusPublished - May 2012

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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