The protective effect of alstonia scholaris r. br. on hepatotoxin-induced acute liver damage

Song Chow Lin, Chun Ching Lin, Yun Ho Lin, S. Supriyatna, Shiow Lin Pan

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49 Citations (Scopus)

Abstract

The hepatoprotective effect of Alstonia scholaris R. Br. on liver injuries induced by carbon tetrachloride (CCl4), β-D-galactosamine, acetaminophen and ethanol were investigated by means of serum-biochemical and histopathological examinations. Post treatment of A scholaris reduced dose-dependently the elevation of serum transaminases level and histopathological changes such as cell necrosis, inflammatory cell infiltration, which were caused by the single administration of 32 μl/kg CCl4 or 600 mg/kg acetaminophen in mice. A. scholaris significantly lowered 288 mg/kg β-D-galactosamine induced serum transaminases elevation in the serum-biochemical analysis in rats. A tendency was also shown to inhibit cell necrosis and inflammatory cell infiltration caused by β-D-galactosamine in histopathological examination. All serological and histopathological effects of A. scholaris were compared with those of Bupleurum chinense, which has been reported previously as a treatment criteria of hepatitis.

Original languageEnglish
Pages (from-to)153-164
Number of pages12
JournalAmerican Journal of Chinese Medicine
Volume24
Issue number2
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Complementary and alternative medicine

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