The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

Thi Thuy Tien Vo, Pei-Ming Chu, Vo Phuoc Tuan, Joyce Si-Liang Te, I-Ta Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

There is growing evidence on the involvement of oxidative stress, which is simply described as the imbalance between oxidants and antioxidants in favor of the former, in the development of periodontal disease that is the most common inflammatory disease in the oral cavity. Thus, the potential of antioxidant phytochemicals as adjunctively preventive and therapeutic agents against the initiation and progression of periodontal disease is a topic of great interest. The current review firstly aims to provide updated insights about the immuno-inflammatory pathway regulated by oxidative stress in periodontal pathology. Then, this work further presents the systemic knowledge of antioxidant phytochemicals, particularly the pharmacological activities, which can be utilized in the prevention and treatment of periodontal disease. Additionally, the challenges and future prospects regarding such a scope are figured out.

Original languageEnglish
Article number1211
Pages (from-to)1-28
Number of pages28
JournalAntioxidants
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 1 2020

Keywords

  • Antioxidant
  • Inflammation
  • Oral cavity
  • Oxidants
  • Oxidative stress
  • Periodontal disease

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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