The prognostic significance of proliferating cell nuclear antigen in patients with lymph node-positive breast cancer

Shyr Ming Sheen-Chen, Hock Liew Eng, Fong Fu Chou, Wei Jen Chen

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in patients with lymph node-positive primary breast cancer. Design: A retrospective study. Setting: A tertiary care hospital. Study Participants: A consecutive series of 123 patients with lymph node- positive primary breast cancer. Intervention: The PCNA-labeling index [(PCNA- positive cells/1000 cells) x 100] was quantified in paraffin-embedded tissue specimens from 123 patients with lymph node-positive primary breast cancer by immunohistochemical staining. Other important clinicopathological variables, including estrogen receptor status, histological grade, lymph node status, primary tumor status, ploidy pattern, S-phase fraction, and TNM staging, were also identified and evaluated. Main Outcome Measures: The influence of the PCNA- labeling index on the disease-free survival rate and overall survival rate. Results: The PCNA-labeling index of the tissue specimens tested from 123 patients ranged from 11% to 82%. The PCNA-labeling index was closely related to primary tumor stains, histological grade, TNM staging, and S- phase fraction. Between patients with a high PCNA-labeling index (>35%) and those with a low PCNA labeling index (≤35%), there were significant (P<.01) differences in both 5-year disease-free survival rates (2% vs 85%) and 5- year overall survival rates (2% vs 92%). When the PCNA-labeling index and all the clinicopathologic variables were entered into a multivariate analysis for either disease-free survival or overall survival by the Cox proportional hazards model, the PCNA-labeling index emerged as an independent prognostic factor. Conclusion: Based on our results, the PCNA-labeling index potentially is a useful prognostic factor for lymph node-positive primary breast cancer.

Original languageEnglish
Pages (from-to)264-267
Number of pages4
JournalArchives of Surgery
Volume132
Issue number3
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

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Proliferating Cell Nuclear Antigen
Lymph Nodes
Breast Neoplasms
Survival Rate
Disease-Free Survival
Neoplasm Staging
S Phase
Ploidies
Tertiary Healthcare
Proportional Hazards Models
Tertiary Care Centers
Estrogen Receptors
Paraffin
Neoplasms
Coloring Agents
Multivariate Analysis
Retrospective Studies
Outcome Assessment (Health Care)
Staining and Labeling

ASJC Scopus subject areas

  • Surgery

Cite this

The prognostic significance of proliferating cell nuclear antigen in patients with lymph node-positive breast cancer. / Sheen-Chen, Shyr Ming; Eng, Hock Liew; Chou, Fong Fu; Chen, Wei Jen.

In: Archives of Surgery, Vol. 132, No. 3, 01.01.1997, p. 264-267.

Research output: Contribution to journalArticle

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title = "The prognostic significance of proliferating cell nuclear antigen in patients with lymph node-positive breast cancer",
abstract = "Objective: To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in patients with lymph node-positive primary breast cancer. Design: A retrospective study. Setting: A tertiary care hospital. Study Participants: A consecutive series of 123 patients with lymph node- positive primary breast cancer. Intervention: The PCNA-labeling index [(PCNA- positive cells/1000 cells) x 100] was quantified in paraffin-embedded tissue specimens from 123 patients with lymph node-positive primary breast cancer by immunohistochemical staining. Other important clinicopathological variables, including estrogen receptor status, histological grade, lymph node status, primary tumor status, ploidy pattern, S-phase fraction, and TNM staging, were also identified and evaluated. Main Outcome Measures: The influence of the PCNA- labeling index on the disease-free survival rate and overall survival rate. Results: The PCNA-labeling index of the tissue specimens tested from 123 patients ranged from 11{\%} to 82{\%}. The PCNA-labeling index was closely related to primary tumor stains, histological grade, TNM staging, and S- phase fraction. Between patients with a high PCNA-labeling index (>35{\%}) and those with a low PCNA labeling index (≤35{\%}), there were significant (P<.01) differences in both 5-year disease-free survival rates (2{\%} vs 85{\%}) and 5- year overall survival rates (2{\%} vs 92{\%}). When the PCNA-labeling index and all the clinicopathologic variables were entered into a multivariate analysis for either disease-free survival or overall survival by the Cox proportional hazards model, the PCNA-labeling index emerged as an independent prognostic factor. Conclusion: Based on our results, the PCNA-labeling index potentially is a useful prognostic factor for lymph node-positive primary breast cancer.",
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N2 - Objective: To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in patients with lymph node-positive primary breast cancer. Design: A retrospective study. Setting: A tertiary care hospital. Study Participants: A consecutive series of 123 patients with lymph node- positive primary breast cancer. Intervention: The PCNA-labeling index [(PCNA- positive cells/1000 cells) x 100] was quantified in paraffin-embedded tissue specimens from 123 patients with lymph node-positive primary breast cancer by immunohistochemical staining. Other important clinicopathological variables, including estrogen receptor status, histological grade, lymph node status, primary tumor status, ploidy pattern, S-phase fraction, and TNM staging, were also identified and evaluated. Main Outcome Measures: The influence of the PCNA- labeling index on the disease-free survival rate and overall survival rate. Results: The PCNA-labeling index of the tissue specimens tested from 123 patients ranged from 11% to 82%. The PCNA-labeling index was closely related to primary tumor stains, histological grade, TNM staging, and S- phase fraction. Between patients with a high PCNA-labeling index (>35%) and those with a low PCNA labeling index (≤35%), there were significant (P<.01) differences in both 5-year disease-free survival rates (2% vs 85%) and 5- year overall survival rates (2% vs 92%). When the PCNA-labeling index and all the clinicopathologic variables were entered into a multivariate analysis for either disease-free survival or overall survival by the Cox proportional hazards model, the PCNA-labeling index emerged as an independent prognostic factor. Conclusion: Based on our results, the PCNA-labeling index potentially is a useful prognostic factor for lymph node-positive primary breast cancer.

AB - Objective: To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in patients with lymph node-positive primary breast cancer. Design: A retrospective study. Setting: A tertiary care hospital. Study Participants: A consecutive series of 123 patients with lymph node- positive primary breast cancer. Intervention: The PCNA-labeling index [(PCNA- positive cells/1000 cells) x 100] was quantified in paraffin-embedded tissue specimens from 123 patients with lymph node-positive primary breast cancer by immunohistochemical staining. Other important clinicopathological variables, including estrogen receptor status, histological grade, lymph node status, primary tumor status, ploidy pattern, S-phase fraction, and TNM staging, were also identified and evaluated. Main Outcome Measures: The influence of the PCNA- labeling index on the disease-free survival rate and overall survival rate. Results: The PCNA-labeling index of the tissue specimens tested from 123 patients ranged from 11% to 82%. The PCNA-labeling index was closely related to primary tumor stains, histological grade, TNM staging, and S- phase fraction. Between patients with a high PCNA-labeling index (>35%) and those with a low PCNA labeling index (≤35%), there were significant (P<.01) differences in both 5-year disease-free survival rates (2% vs 85%) and 5- year overall survival rates (2% vs 92%). When the PCNA-labeling index and all the clinicopathologic variables were entered into a multivariate analysis for either disease-free survival or overall survival by the Cox proportional hazards model, the PCNA-labeling index emerged as an independent prognostic factor. Conclusion: Based on our results, the PCNA-labeling index potentially is a useful prognostic factor for lymph node-positive primary breast cancer.

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