The prognostic significance of nuclear CSE1L in urinary bladder urothelial carcinomas

Chun Chao Chang, Cheng Jeng Tai, Tzu Cheng Su, Ko Hung Shen, Shu Hui Lin, Chung Min Yeh, Kun Tu Yeh, Yueh Min Lin, Ming Chung Jiang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Prognosis of urinary bladder urothelial carcinomas may be challenging; many tumors with similar histopathologic features show significantly different clinical outcomes. CSE1L, the chromosome segregation 1-like protein, is both a cytoplasmic and nuclear protein. We investigated the cytoplasmic/nuclear expression pattern of CSE1L to determine its potential prognostic significance. In immunohistochemical analysis, nonneoplastic urothelium showed faint CSE1L staining, whereas all tumors in the bladder cancer specimens had significant staining for CSE1L (100%, or 38/38). CSE1L cytoplasmic/nuclear staining was defined based on relative staining intensity. A total of 20 (52.6%) of 38 cancer specimens had strong nuclear CSE1L staining, and 44.7.3% (17/38) of the samples had strong cytoplasmic CSE1L staining. Bladder urothelial carcinomas with high CSE1L nuclear staining had a significantly lower overall survival rate (log-rank test, P =.011). CSE1L expression was not correlated with tumor stage, likely reflecting the faultiness of current urothelial carcinoma evaluation methods. Our results suggest that nuclear CSE1L may play an oncogenic role in bladder tumor progression and that immunohistochemical staining of nuclear CSE1L may be useful for the prognosis of bladder urothelial carcinomas.

Original languageEnglish
Pages (from-to)362-368
Number of pages7
JournalAnnals of Diagnostic Pathology
Volume16
Issue number5
DOIs
Publication statusPublished - Oct 2012

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Keywords

  • CSE1L
  • Prognosis
  • Tumor markers
  • Urinary bladder cancer
  • Urothelial carcinomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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