The preventive effects of G115 on balloon injury-induced neointima formation in rats

Chieh Hsi Wu, Byi Rong Tsai, Wen Tsong Hsieh, Gee Yat Chang, Simon J T Mao, Weng Cheng Chang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

After percutaneous transluminal coronary angioplasty (PTCA), 30-50% of the patients may present with restenosis within 6 months. The aim of this study was to search for a preventive remedy against the balloon injury-induced neointima formation. Ginseng, with its wide indications on immune and cardiovascular functions, has prompted us to explore its role in neointima formation. In the present study, we aimed to explore if a standardized Panax Ginseng extract G115 was able to inhibit neointimal formation. With BrdU luminencence assay, maximal proliferation of rat smooth muscle cells was reduced to 24% of control values by G115. Norepinephrine-induced vasocontraction was antagonized in 21% and 44% by 1.44mg/ml and 2.88mg/ml of G115, respectively. Neointima-to-lumen area ratio of balloon-injured rat carotid arteries was reduced 77.3% by G115 as compared to the sham control. These results demonstrate the preventive effects of ginsenosides on angioplasty-mediated neointima formation.

Original languageEnglish
Pages (from-to)669-679
Number of pages11
JournalLife Sciences
Volume70
Issue number6
DOIs
Publication statusPublished - Dec 28 2001
Externally publishedYes

Fingerprint

Neointima
Balloons
Rats
Ginsenosides
Panax
Wounds and Injuries
Bromodeoxyuridine
Muscle
Assays
Norepinephrine
Cells
Coronary Balloon Angioplasty
Angioplasty
Carotid Arteries
Smooth Muscle Myocytes

Keywords

  • Angioplasty
  • G115
  • Ginsenosides
  • Restenosis, Panax Ginseng

ASJC Scopus subject areas

  • Pharmacology

Cite this

Wu, C. H., Tsai, B. R., Hsieh, W. T., Chang, G. Y., Mao, S. J. T., & Chang, W. C. (2001). The preventive effects of G115 on balloon injury-induced neointima formation in rats. Life Sciences, 70(6), 669-679. https://doi.org/10.1016/S0024-3205(01)01442-4

The preventive effects of G115 on balloon injury-induced neointima formation in rats. / Wu, Chieh Hsi; Tsai, Byi Rong; Hsieh, Wen Tsong; Chang, Gee Yat; Mao, Simon J T; Chang, Weng Cheng.

In: Life Sciences, Vol. 70, No. 6, 28.12.2001, p. 669-679.

Research output: Contribution to journalArticle

Wu, Chieh Hsi ; Tsai, Byi Rong ; Hsieh, Wen Tsong ; Chang, Gee Yat ; Mao, Simon J T ; Chang, Weng Cheng. / The preventive effects of G115 on balloon injury-induced neointima formation in rats. In: Life Sciences. 2001 ; Vol. 70, No. 6. pp. 669-679.
@article{a847e4d18df9443ba6defb73fba54e3c,
title = "The preventive effects of G115 on balloon injury-induced neointima formation in rats",
abstract = "After percutaneous transluminal coronary angioplasty (PTCA), 30-50{\%} of the patients may present with restenosis within 6 months. The aim of this study was to search for a preventive remedy against the balloon injury-induced neointima formation. Ginseng, with its wide indications on immune and cardiovascular functions, has prompted us to explore its role in neointima formation. In the present study, we aimed to explore if a standardized Panax Ginseng extract G115 was able to inhibit neointimal formation. With BrdU luminencence assay, maximal proliferation of rat smooth muscle cells was reduced to 24{\%} of control values by G115. Norepinephrine-induced vasocontraction was antagonized in 21{\%} and 44{\%} by 1.44mg/ml and 2.88mg/ml of G115, respectively. Neointima-to-lumen area ratio of balloon-injured rat carotid arteries was reduced 77.3{\%} by G115 as compared to the sham control. These results demonstrate the preventive effects of ginsenosides on angioplasty-mediated neointima formation.",
keywords = "Angioplasty, G115, Ginsenosides, Restenosis, Panax Ginseng",
author = "Wu, {Chieh Hsi} and Tsai, {Byi Rong} and Hsieh, {Wen Tsong} and Chang, {Gee Yat} and Mao, {Simon J T} and Chang, {Weng Cheng}",
year = "2001",
month = "12",
day = "28",
doi = "10.1016/S0024-3205(01)01442-4",
language = "English",
volume = "70",
pages = "669--679",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - The preventive effects of G115 on balloon injury-induced neointima formation in rats

AU - Wu, Chieh Hsi

AU - Tsai, Byi Rong

AU - Hsieh, Wen Tsong

AU - Chang, Gee Yat

AU - Mao, Simon J T

AU - Chang, Weng Cheng

PY - 2001/12/28

Y1 - 2001/12/28

N2 - After percutaneous transluminal coronary angioplasty (PTCA), 30-50% of the patients may present with restenosis within 6 months. The aim of this study was to search for a preventive remedy against the balloon injury-induced neointima formation. Ginseng, with its wide indications on immune and cardiovascular functions, has prompted us to explore its role in neointima formation. In the present study, we aimed to explore if a standardized Panax Ginseng extract G115 was able to inhibit neointimal formation. With BrdU luminencence assay, maximal proliferation of rat smooth muscle cells was reduced to 24% of control values by G115. Norepinephrine-induced vasocontraction was antagonized in 21% and 44% by 1.44mg/ml and 2.88mg/ml of G115, respectively. Neointima-to-lumen area ratio of balloon-injured rat carotid arteries was reduced 77.3% by G115 as compared to the sham control. These results demonstrate the preventive effects of ginsenosides on angioplasty-mediated neointima formation.

AB - After percutaneous transluminal coronary angioplasty (PTCA), 30-50% of the patients may present with restenosis within 6 months. The aim of this study was to search for a preventive remedy against the balloon injury-induced neointima formation. Ginseng, with its wide indications on immune and cardiovascular functions, has prompted us to explore its role in neointima formation. In the present study, we aimed to explore if a standardized Panax Ginseng extract G115 was able to inhibit neointimal formation. With BrdU luminencence assay, maximal proliferation of rat smooth muscle cells was reduced to 24% of control values by G115. Norepinephrine-induced vasocontraction was antagonized in 21% and 44% by 1.44mg/ml and 2.88mg/ml of G115, respectively. Neointima-to-lumen area ratio of balloon-injured rat carotid arteries was reduced 77.3% by G115 as compared to the sham control. These results demonstrate the preventive effects of ginsenosides on angioplasty-mediated neointima formation.

KW - Angioplasty

KW - G115

KW - Ginsenosides

KW - Restenosis, Panax Ginseng

UR - http://www.scopus.com/inward/record.url?scp=0035966243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035966243&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(01)01442-4

DO - 10.1016/S0024-3205(01)01442-4

M3 - Article

C2 - 11833717

AN - SCOPUS:0035966243

VL - 70

SP - 669

EP - 679

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 6

ER -