The preparation and characterization of solid dispersions on pellets using a fluidized-bed system

Hsiu O. Ho, Huei Lin Su, Tsuimin Tsai, Ming Thau Sheu

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45 Citations (Scopus)

Abstract

In this study, solid dispersions of a poorly water-soluble drug, nifedipine, were prepared in hydroxypropylmethylcellulose (HPMC) on sugar spheres using a fluidized-bed coating system and characterized by differential scanning calorimetry (DSC) and dissolution measurements. A mixture of acetone and water (7:3) was found to be suitable as a spraying solution for simultaneous application of nifedipine and HPMC. DSC studies showed that the peak corresponding to the melting point of nifedipine became broadened when nifedipine was incorporated in a solid dispersion with HPMC at both ratios of 1:1 and 1:3. The results demonstrated that dissolution rates were fastest at the lowest nifedipine loading. Furthermore, the dissolution rate of nifedipine increased as more HPMC was added to the solid dispersions. The enhancement in the dissolution rate of nifedipine upon addition of Tween 80 in simulated gastric acid was attributed to the solubilizing effect of Tween 80 on nifedipine. Tween 80 had less influence when nifedipine was incorporated in solid dispersions containing higher fractions of HPMC.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume139
Issue number1-2
DOIs
Publication statusPublished - Aug 9 1996

Keywords

  • Fluidized-bed system
  • Hydroxypropylmethylcellulose (HPMC)
  • Nifedipine
  • Solid dispersions

ASJC Scopus subject areas

  • Pharmaceutical Science

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