The predictive value of serum testosterone level on the functional outcomes after acute ischemic stroke in males

Pin Wen Liao, Jen Tse Chen, Shih Ping Liu, Chen Hsun Ho

Research output: Contribution to journalArticle

Abstract

Introduction: We aimed to evaluate the predictive value of sex hormone levels on 3-month functional outcomes after acute ischemic stroke (AIS) in males. Materials and methods: A total of 110 male AIS patients were included in this prospective study. Serum levels of testosterone and estradiol were measured at admission. The National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) were measured at admission and after 3 months. A mRS score ≥3 was considered as a poor functional outcome. Results: The median age of the 110 subjects was 62.0 [23.3] years (range 35–93 years). Univariate logistic regression revealed that bioavailable testosterone, free testosterone, age, NIHSS at admission, mRS at admission, and prior ischemic stroke were associated with a poor functional outcome (mRS score ≥3) at 3 months. In multivariate analysis, only age, NIHSS at admission, and mRS at admission were independent predictors. Conclusions: After controlling the covariates, bioavailable and free testosterone levels are not associated with the 3-month mRS in male patients with AIS. Age, NIHSS at admission, and mRS at admission are robust predictors for the functional outcomes.

Original languageEnglish
JournalAging Male
DOIs
Publication statusAccepted/In press - Jan 1 2019

Keywords

  • functional outcome
  • ischemic stroke
  • predictor
  • recovery
  • Testosterone

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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