The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer

Chien Hung Lee, Sheau Fang Yang, Chiung Yu Peng, Ruei Nian Li, Yu Chieh Chen, Te Fu Chan, Eing Mei Tsai, Fu Chen Kuo, Joh Jong Huang, Hsiu Ting Tsai, Yu Hsiu Hung, Hsiao Ling Huang, Sharon Tsai, Ming Tsang Wu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Although cooking emission from high-temperature frying has been deemed a Group 2A carcinogen by the International Agency for Research on Cancer, little is known about its impact on cervical tumorigenesis. To investigate the precancerous consequence of cooking oil fumes on cervical intraepithelial neoplasm (CIN), a community-based case-control study, which takes all known risk factors into consideration, was conducted in Taiwan. From 2003 to 2008, in a Pap smear screening and biopsy examination network, 206 pathology-verified women with inflammations/atypical squamous cells of undetermined significance or CIN grade-1 (CIN1) and 73 with CIN2-3 (defined as low-grade squamous intraepithelial lesions (LGSIL) and high-grade squamous intraepithelial lesions (HGSIL), respectively); and 1,200 area-and-age-matched controls with negative cytology were recruited. Multinomial logistic regression was applied in the multivariate analysis to determine the likelihood of contracting LGSIL or HGSIL. The risks of the two lesions increased with the increase of carcinogenic high-risk human papillomavirus DNA load, with a clear dose-response relationship. Chefs were observed to experience a 7.9-fold elevated HGSIL risk. Kitchens with poor fume ventilation during the main cooking life-stage correlated to a 3.7-fold risk of HGSIL, but not for LGSIL. More than 1 hr of daily cooking in kitchens with poor fume conditions appeared to confer an 8.4-fold HGSIL risk, with an 8.3-fold heterogeneously higher odds ratio than that (aOR = 1.0) for LGSIL. Similar risk pattern has been reproduced among never-smoking women. Our findings demonstrate the association between indoor exposure to cooking fumes from heated oil and the late development of cervical precancerous lesions. This final conclusion needs to be verified by future research.

Original languageEnglish
Pages (from-to)932-941
Number of pages10
JournalInternational Journal of Cancer
Volume127
Issue number4
DOIs
Publication statusPublished - Aug 15 2010
Externally publishedYes

Fingerprint

Cooking
Uterine Cervical Neoplasms
Oils
Cervical Intraepithelial Neoplasia
International Agencies
Squamous Intraepithelial Lesions of the Cervix
Papanicolaou Test
Taiwan
Carcinogens
Ventilation
Cell Biology
Case-Control Studies
Carcinogenesis
Multivariate Analysis
Logistic Models
Smoking
Odds Ratio
Pathology
Inflammation
Biopsy

Keywords

  • Cervical cancer
  • Cervical intraepithelial neoplasm
  • Cooking oil fumes
  • High-grade squamous cell intraepithelial lesions
  • Human papillomavirus

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Lee, C. H., Yang, S. F., Peng, C. Y., Li, R. N., Chen, Y. C., Chan, T. F., ... Wu, M. T. (2010). The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer. International Journal of Cancer, 127(4), 932-941. https://doi.org/10.1002/ijc.25108

The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer. / Lee, Chien Hung; Yang, Sheau Fang; Peng, Chiung Yu; Li, Ruei Nian; Chen, Yu Chieh; Chan, Te Fu; Tsai, Eing Mei; Kuo, Fu Chen; Huang, Joh Jong; Tsai, Hsiu Ting; Hung, Yu Hsiu; Huang, Hsiao Ling; Tsai, Sharon; Wu, Ming Tsang.

In: International Journal of Cancer, Vol. 127, No. 4, 15.08.2010, p. 932-941.

Research output: Contribution to journalArticle

Lee, CH, Yang, SF, Peng, CY, Li, RN, Chen, YC, Chan, TF, Tsai, EM, Kuo, FC, Huang, JJ, Tsai, HT, Hung, YH, Huang, HL, Tsai, S & Wu, MT 2010, 'The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer', International Journal of Cancer, vol. 127, no. 4, pp. 932-941. https://doi.org/10.1002/ijc.25108
Lee, Chien Hung ; Yang, Sheau Fang ; Peng, Chiung Yu ; Li, Ruei Nian ; Chen, Yu Chieh ; Chan, Te Fu ; Tsai, Eing Mei ; Kuo, Fu Chen ; Huang, Joh Jong ; Tsai, Hsiu Ting ; Hung, Yu Hsiu ; Huang, Hsiao Ling ; Tsai, Sharon ; Wu, Ming Tsang. / The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer. In: International Journal of Cancer. 2010 ; Vol. 127, No. 4. pp. 932-941.
@article{d9f9d4713dd940f08f92889a079243ba,
title = "The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer",
abstract = "Although cooking emission from high-temperature frying has been deemed a Group 2A carcinogen by the International Agency for Research on Cancer, little is known about its impact on cervical tumorigenesis. To investigate the precancerous consequence of cooking oil fumes on cervical intraepithelial neoplasm (CIN), a community-based case-control study, which takes all known risk factors into consideration, was conducted in Taiwan. From 2003 to 2008, in a Pap smear screening and biopsy examination network, 206 pathology-verified women with inflammations/atypical squamous cells of undetermined significance or CIN grade-1 (CIN1) and 73 with CIN2-3 (defined as low-grade squamous intraepithelial lesions (LGSIL) and high-grade squamous intraepithelial lesions (HGSIL), respectively); and 1,200 area-and-age-matched controls with negative cytology were recruited. Multinomial logistic regression was applied in the multivariate analysis to determine the likelihood of contracting LGSIL or HGSIL. The risks of the two lesions increased with the increase of carcinogenic high-risk human papillomavirus DNA load, with a clear dose-response relationship. Chefs were observed to experience a 7.9-fold elevated HGSIL risk. Kitchens with poor fume ventilation during the main cooking life-stage correlated to a 3.7-fold risk of HGSIL, but not for LGSIL. More than 1 hr of daily cooking in kitchens with poor fume conditions appeared to confer an 8.4-fold HGSIL risk, with an 8.3-fold heterogeneously higher odds ratio than that (aOR = 1.0) for LGSIL. Similar risk pattern has been reproduced among never-smoking women. Our findings demonstrate the association between indoor exposure to cooking fumes from heated oil and the late development of cervical precancerous lesions. This final conclusion needs to be verified by future research.",
keywords = "Cervical cancer, Cervical intraepithelial neoplasm, Cooking oil fumes, High-grade squamous cell intraepithelial lesions, Human papillomavirus",
author = "Lee, {Chien Hung} and Yang, {Sheau Fang} and Peng, {Chiung Yu} and Li, {Ruei Nian} and Chen, {Yu Chieh} and Chan, {Te Fu} and Tsai, {Eing Mei} and Kuo, {Fu Chen} and Huang, {Joh Jong} and Tsai, {Hsiu Ting} and Hung, {Yu Hsiu} and Huang, {Hsiao Ling} and Sharon Tsai and Wu, {Ming Tsang}",
year = "2010",
month = "8",
day = "15",
doi = "10.1002/ijc.25108",
language = "English",
volume = "127",
pages = "932--941",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer

AU - Lee, Chien Hung

AU - Yang, Sheau Fang

AU - Peng, Chiung Yu

AU - Li, Ruei Nian

AU - Chen, Yu Chieh

AU - Chan, Te Fu

AU - Tsai, Eing Mei

AU - Kuo, Fu Chen

AU - Huang, Joh Jong

AU - Tsai, Hsiu Ting

AU - Hung, Yu Hsiu

AU - Huang, Hsiao Ling

AU - Tsai, Sharon

AU - Wu, Ming Tsang

PY - 2010/8/15

Y1 - 2010/8/15

N2 - Although cooking emission from high-temperature frying has been deemed a Group 2A carcinogen by the International Agency for Research on Cancer, little is known about its impact on cervical tumorigenesis. To investigate the precancerous consequence of cooking oil fumes on cervical intraepithelial neoplasm (CIN), a community-based case-control study, which takes all known risk factors into consideration, was conducted in Taiwan. From 2003 to 2008, in a Pap smear screening and biopsy examination network, 206 pathology-verified women with inflammations/atypical squamous cells of undetermined significance or CIN grade-1 (CIN1) and 73 with CIN2-3 (defined as low-grade squamous intraepithelial lesions (LGSIL) and high-grade squamous intraepithelial lesions (HGSIL), respectively); and 1,200 area-and-age-matched controls with negative cytology were recruited. Multinomial logistic regression was applied in the multivariate analysis to determine the likelihood of contracting LGSIL or HGSIL. The risks of the two lesions increased with the increase of carcinogenic high-risk human papillomavirus DNA load, with a clear dose-response relationship. Chefs were observed to experience a 7.9-fold elevated HGSIL risk. Kitchens with poor fume ventilation during the main cooking life-stage correlated to a 3.7-fold risk of HGSIL, but not for LGSIL. More than 1 hr of daily cooking in kitchens with poor fume conditions appeared to confer an 8.4-fold HGSIL risk, with an 8.3-fold heterogeneously higher odds ratio than that (aOR = 1.0) for LGSIL. Similar risk pattern has been reproduced among never-smoking women. Our findings demonstrate the association between indoor exposure to cooking fumes from heated oil and the late development of cervical precancerous lesions. This final conclusion needs to be verified by future research.

AB - Although cooking emission from high-temperature frying has been deemed a Group 2A carcinogen by the International Agency for Research on Cancer, little is known about its impact on cervical tumorigenesis. To investigate the precancerous consequence of cooking oil fumes on cervical intraepithelial neoplasm (CIN), a community-based case-control study, which takes all known risk factors into consideration, was conducted in Taiwan. From 2003 to 2008, in a Pap smear screening and biopsy examination network, 206 pathology-verified women with inflammations/atypical squamous cells of undetermined significance or CIN grade-1 (CIN1) and 73 with CIN2-3 (defined as low-grade squamous intraepithelial lesions (LGSIL) and high-grade squamous intraepithelial lesions (HGSIL), respectively); and 1,200 area-and-age-matched controls with negative cytology were recruited. Multinomial logistic regression was applied in the multivariate analysis to determine the likelihood of contracting LGSIL or HGSIL. The risks of the two lesions increased with the increase of carcinogenic high-risk human papillomavirus DNA load, with a clear dose-response relationship. Chefs were observed to experience a 7.9-fold elevated HGSIL risk. Kitchens with poor fume ventilation during the main cooking life-stage correlated to a 3.7-fold risk of HGSIL, but not for LGSIL. More than 1 hr of daily cooking in kitchens with poor fume conditions appeared to confer an 8.4-fold HGSIL risk, with an 8.3-fold heterogeneously higher odds ratio than that (aOR = 1.0) for LGSIL. Similar risk pattern has been reproduced among never-smoking women. Our findings demonstrate the association between indoor exposure to cooking fumes from heated oil and the late development of cervical precancerous lesions. This final conclusion needs to be verified by future research.

KW - Cervical cancer

KW - Cervical intraepithelial neoplasm

KW - Cooking oil fumes

KW - High-grade squamous cell intraepithelial lesions

KW - Human papillomavirus

UR - http://www.scopus.com/inward/record.url?scp=77954696859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954696859&partnerID=8YFLogxK

U2 - 10.1002/ijc.25108

DO - 10.1002/ijc.25108

M3 - Article

C2 - 20013811

AN - SCOPUS:77954696859

VL - 127

SP - 932

EP - 941

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -