The powdered root of eurycoma longifolia jack improves beta-cell number and pancreatic islet performance through pdx1 induction and shows antihyperglycemic activity in db/db mice

Chi Hao Tsai, Te Chao Fang, Po Lin Liao, Jiunn Wang Liao, Yen Ju Chan, Ching Hao Li, Yu Wen Cheng

Research output: Contribution to journalArticle

Abstract

Non-insulin-dependent diabetes mellitus (NIDDM) is a common metabolic disorder worldwide. In addition to the chief feature of long-standing hyperglycemia, dyslipidemia, hyperinsulinemia, and a number of complications develop in parallel. It is believed that an adequate control of blood glucose levels can cause these complications to go into remission. This study was performed to evaluate the antidiabetic activity of Eurycoma longifolia Jack (EL) in vivo. The blood-glucose-lowering activity of EL was studied in db/db mice administered crude powdered EL root (25, 50, and 100 mg/kg) orally for eight weeks. At the end of the study, HbA1c, insulin, plasma lipid levels, and histopathology were performed. Powdered EL root showed significant antihyperglycemic activity along with the control of body weight. After eight weeks of treatment, both the blood cholesterol level and the glycogen deposit in hepatocytes were remarkably lower, whereas the secreting insulin level was elevated. An improvement in islet performance was manifested as an increase in beta-cell number and pancreatic and duodenal homeobox 1 (PDX1) expression. Neogenesis or formation of new islets from pancreatic duct epithelial cells seen in the EL-treated group was encouraging. This study confirms the antihyperglycemic activity of EL through PDX1-associated beta-cell expansion resulting in an enhancement of islet performance.

Original languageEnglish
Article number2111
Pages (from-to)1-16
Number of pages16
JournalNutrients
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Beta-cell
  • Diabetes mellitus
  • Eurycoma longifolia
  • Insulin
  • PDX1

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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