The potential role of strontium ranelate in treating particle-induced osteolysis

Yung Chang Lu, Ting Kuo Chang, Shu Ting Yeh, Hsu Wei Fang, Chun Yen Lin, Lin I. Hsu, Chun Hsiung Huang, Chang Hung Huang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ultra high molecular weight polyethylene (UHMWPE) wear-particle-induced osteolysis is one of the major issues affecting the long-term survival of total joint prostheses. Currently, there are no effective therapeutic options to prevent osteolysis from occurring. The aim of this study was to evaluate the role of strontium ranelate (SR) in reducing the risk of particle-induced osteolysis. Forty-eight C57BL/6J ultra-high molecular weight polyethylene (UHMWPE) particle-induced murine calvarial osteolysis models were used. The mice were randomized into four groups as: sham (Group 1), UHMWPE particles (Group 2), and SR with UHMWPE particles (Group 3 and Group 4). Groups 1 to 3 were sacrificed at two weeks and group 4 was sacrificed at the fourth week. The skulls were then analyzed with a high-resolution micro-CT. Histological evaluation was then conducted and osteoclast numbers were analyzed for comparison. Based on the micro-CT, percentage bone volume and trabecular thickness were found to be significantly higher in Group 4 than in Group 2 (p < 0.001). Osteoclast numbers in SR treated groups (Group 3 and Group 4) were reduced when compared to groups that did not receive SR treatment (Group 2). These results indicated that SR treatment helps to increase bone volume percentage and trabecular thickness and also suppresses osteoclast proliferation. It is suggested that oral SR treatment could serve as an alternative therapy for preventing particle-induced osteolysis.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalActa Biomaterialia
Volume20
DOIs
Publication statusPublished - Jul 1 2015
Externally publishedYes

Fingerprint

strontium ranelate
Osteolysis
Strontium
Ultrahigh molecular weight polyethylenes
Osteoclasts
Bone
Joint prostheses
Joint Prosthesis
Therapeutics
Complementary Therapies
Skull
Wear of materials
Bone and Bones

Keywords

  • Murine calvarial model
  • Particle-induced osteolysis
  • Strontium ranelate
  • Wear debris

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

The potential role of strontium ranelate in treating particle-induced osteolysis. / Lu, Yung Chang; Chang, Ting Kuo; Yeh, Shu Ting; Fang, Hsu Wei; Lin, Chun Yen; Hsu, Lin I.; Huang, Chun Hsiung; Huang, Chang Hung.

In: Acta Biomaterialia, Vol. 20, 01.07.2015, p. 147-154.

Research output: Contribution to journalArticle

Lu, YC, Chang, TK, Yeh, ST, Fang, HW, Lin, CY, Hsu, LI, Huang, CH & Huang, CH 2015, 'The potential role of strontium ranelate in treating particle-induced osteolysis', Acta Biomaterialia, vol. 20, pp. 147-154. https://doi.org/10.1016/j.actbio.2015.03.034
Lu, Yung Chang ; Chang, Ting Kuo ; Yeh, Shu Ting ; Fang, Hsu Wei ; Lin, Chun Yen ; Hsu, Lin I. ; Huang, Chun Hsiung ; Huang, Chang Hung. / The potential role of strontium ranelate in treating particle-induced osteolysis. In: Acta Biomaterialia. 2015 ; Vol. 20. pp. 147-154.
@article{615bcd20764a401fa0c61aa7469a9e4f,
title = "The potential role of strontium ranelate in treating particle-induced osteolysis",
abstract = "Ultra high molecular weight polyethylene (UHMWPE) wear-particle-induced osteolysis is one of the major issues affecting the long-term survival of total joint prostheses. Currently, there are no effective therapeutic options to prevent osteolysis from occurring. The aim of this study was to evaluate the role of strontium ranelate (SR) in reducing the risk of particle-induced osteolysis. Forty-eight C57BL/6J ultra-high molecular weight polyethylene (UHMWPE) particle-induced murine calvarial osteolysis models were used. The mice were randomized into four groups as: sham (Group 1), UHMWPE particles (Group 2), and SR with UHMWPE particles (Group 3 and Group 4). Groups 1 to 3 were sacrificed at two weeks and group 4 was sacrificed at the fourth week. The skulls were then analyzed with a high-resolution micro-CT. Histological evaluation was then conducted and osteoclast numbers were analyzed for comparison. Based on the micro-CT, percentage bone volume and trabecular thickness were found to be significantly higher in Group 4 than in Group 2 (p < 0.001). Osteoclast numbers in SR treated groups (Group 3 and Group 4) were reduced when compared to groups that did not receive SR treatment (Group 2). These results indicated that SR treatment helps to increase bone volume percentage and trabecular thickness and also suppresses osteoclast proliferation. It is suggested that oral SR treatment could serve as an alternative therapy for preventing particle-induced osteolysis.",
keywords = "Murine calvarial model, Particle-induced osteolysis, Strontium ranelate, Wear debris",
author = "Lu, {Yung Chang} and Chang, {Ting Kuo} and Yeh, {Shu Ting} and Fang, {Hsu Wei} and Lin, {Chun Yen} and Hsu, {Lin I.} and Huang, {Chun Hsiung} and Huang, {Chang Hung}",
year = "2015",
month = "7",
day = "1",
doi = "10.1016/j.actbio.2015.03.034",
language = "English",
volume = "20",
pages = "147--154",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - The potential role of strontium ranelate in treating particle-induced osteolysis

AU - Lu, Yung Chang

AU - Chang, Ting Kuo

AU - Yeh, Shu Ting

AU - Fang, Hsu Wei

AU - Lin, Chun Yen

AU - Hsu, Lin I.

AU - Huang, Chun Hsiung

AU - Huang, Chang Hung

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Ultra high molecular weight polyethylene (UHMWPE) wear-particle-induced osteolysis is one of the major issues affecting the long-term survival of total joint prostheses. Currently, there are no effective therapeutic options to prevent osteolysis from occurring. The aim of this study was to evaluate the role of strontium ranelate (SR) in reducing the risk of particle-induced osteolysis. Forty-eight C57BL/6J ultra-high molecular weight polyethylene (UHMWPE) particle-induced murine calvarial osteolysis models were used. The mice were randomized into four groups as: sham (Group 1), UHMWPE particles (Group 2), and SR with UHMWPE particles (Group 3 and Group 4). Groups 1 to 3 were sacrificed at two weeks and group 4 was sacrificed at the fourth week. The skulls were then analyzed with a high-resolution micro-CT. Histological evaluation was then conducted and osteoclast numbers were analyzed for comparison. Based on the micro-CT, percentage bone volume and trabecular thickness were found to be significantly higher in Group 4 than in Group 2 (p < 0.001). Osteoclast numbers in SR treated groups (Group 3 and Group 4) were reduced when compared to groups that did not receive SR treatment (Group 2). These results indicated that SR treatment helps to increase bone volume percentage and trabecular thickness and also suppresses osteoclast proliferation. It is suggested that oral SR treatment could serve as an alternative therapy for preventing particle-induced osteolysis.

AB - Ultra high molecular weight polyethylene (UHMWPE) wear-particle-induced osteolysis is one of the major issues affecting the long-term survival of total joint prostheses. Currently, there are no effective therapeutic options to prevent osteolysis from occurring. The aim of this study was to evaluate the role of strontium ranelate (SR) in reducing the risk of particle-induced osteolysis. Forty-eight C57BL/6J ultra-high molecular weight polyethylene (UHMWPE) particle-induced murine calvarial osteolysis models were used. The mice were randomized into four groups as: sham (Group 1), UHMWPE particles (Group 2), and SR with UHMWPE particles (Group 3 and Group 4). Groups 1 to 3 were sacrificed at two weeks and group 4 was sacrificed at the fourth week. The skulls were then analyzed with a high-resolution micro-CT. Histological evaluation was then conducted and osteoclast numbers were analyzed for comparison. Based on the micro-CT, percentage bone volume and trabecular thickness were found to be significantly higher in Group 4 than in Group 2 (p < 0.001). Osteoclast numbers in SR treated groups (Group 3 and Group 4) were reduced when compared to groups that did not receive SR treatment (Group 2). These results indicated that SR treatment helps to increase bone volume percentage and trabecular thickness and also suppresses osteoclast proliferation. It is suggested that oral SR treatment could serve as an alternative therapy for preventing particle-induced osteolysis.

KW - Murine calvarial model

KW - Particle-induced osteolysis

KW - Strontium ranelate

KW - Wear debris

UR - http://www.scopus.com/inward/record.url?scp=84929506464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929506464&partnerID=8YFLogxK

U2 - 10.1016/j.actbio.2015.03.034

DO - 10.1016/j.actbio.2015.03.034

M3 - Article

VL - 20

SP - 147

EP - 154

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

ER -