The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: In vitro and in vivo evaluation

Ling Chuan Hsu, Bou Yue Peng, May Show Chen, Bahruddin Thalib, Muhammad Ruslin, Tran Dang Xuan Tung, Hsin Hua Chou, Keng Liang Ou

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

In this study, the wound healing properties of the gelatin-based hydrogel (GBH) wound dressing combined with adipose-derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell growth and promoted cell differentiation (adipogenesis and osteogenesis) in comparison to the ADSCs harvested from the mouse in vitro. Moreover, the in vivo results also indicated that the GBH wound dressing combined with ADSCs and its culture medium could potentially accelerate wound healing in the mouse and porcine models. The ADSCs presented a possibility of recovery from wounds and injuries through skin regeneration. Therefore, both in vitro and in vivo results demonstrated that the ADSCs can potentially be an effective clinical treatment through the GBH wound dressing, which is a promising evidence-based complementary and alternative medicine for skin regeneration.

Original languageEnglish
Pages (from-to)278-285
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume107
Issue number2
DOIs
Publication statusPublished - Feb 1 2019

Keywords

  • adipose-derived stem cells
  • hydrogel
  • skin regeneration
  • wound healing

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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