The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer

Bor Ching Sheu, Ho Hsiung Lin, Daw Yuan Chang, Hong Nerng Ho, Su Cheng Huang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF-RI) as a potential biochemical marker in women with cervical cancer. Design A prospective, case-controlled study. Participants Seventy-one women with cervical cancer and 33 women with myoma were enrolled in this study. Methods Pre-operative serum levels of sTNF-RI were measured with a standard enzyme-linked immunosorbent assay utilising murine monoclonal antibody against sTNF-RI. Main outcome measures All data in both groups were evaluated and correlated with the pre-operative serum levels of sTNF-RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression. Results The mean serum level of sTNF-RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF-RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF-RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF-RI and tumour size (r=−0.622, P < 0.0001). Conclusions Decreased pre-operative serum levels of sTNF-RI are observed in women with cervical cancer. The results do not support that the use of sTNF-RI as a biochemical marker for cervical cancer.

Original languageEnglish
Pages (from-to)1314-1319
Number of pages6
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume104
Issue number11
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer. / Sheu, Bor Ching; Lin, Ho Hsiung; Chang, Daw Yuan; Ho, Hong Nerng; Huang, Su Cheng.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 104, No. 11, 01.01.1997, p. 1314-1319.

Research output: Contribution to journalArticle

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abstract = "Objectives To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF-RI) as a potential biochemical marker in women with cervical cancer. Design A prospective, case-controlled study. Participants Seventy-one women with cervical cancer and 33 women with myoma were enrolled in this study. Methods Pre-operative serum levels of sTNF-RI were measured with a standard enzyme-linked immunosorbent assay utilising murine monoclonal antibody against sTNF-RI. Main outcome measures All data in both groups were evaluated and correlated with the pre-operative serum levels of sTNF-RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression. Results The mean serum level of sTNF-RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF-RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF-RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF-RI and tumour size (r=−0.622, P < 0.0001). Conclusions Decreased pre-operative serum levels of sTNF-RI are observed in women with cervical cancer. The results do not support that the use of sTNF-RI as a biochemical marker for cervical cancer.",
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