TY - JOUR
T1 - The potential of nano-porous surface structure for pain therapeutic applications
T2 - Surface properties and evaluation of pain perception
AU - Wu, Ching Zong
AU - Hsu, Ling Chuan
AU - Chou, Hsin Hua
AU - Barnkob, Sanne
AU - Eggert, Tobias
AU - Nielsen, Pernille Lind
AU - Young, Roger
AU - Vase, Lene
AU - Wang, Kelun
AU - Svensson, Peter
AU - Ou, Keng Liang
AU - Baad-Hansen, Lene
N1 - Funding Information:
Funding: The authors are grateful to the Biomate Medical Devices Technology co., ltd and ANMC Healthcare, Inc. for their support with experimental devices and testing instruments. This study is also supported in part by Lo-Hsu Foundation Lotung Poh-Ai Hospital (104-E126) and the Danish Dental Association. Special thanks are extended to the Department of Dentistry and Oral Health, Aarhus University, Denmark and 3D Global Biotech Inc., Taiwan, for their skillful technical assistance.
Funding Information:
The authors are grateful to the Biomate Medical Devices Technology co., ltd and ANMC Healthcare, Inc. for their support with experimental devices and testing instruments. This study is also supported in part by Lo-Hsu Foundation Lotung Poh-Ai Hospital (104-E126) and the Danish Dental Association. Special thanks are extended to the Department of Dentistry and Oral Health, Aarhus University, Denmark and 3D Global Biotech Inc., Taiwan, for their skillful technical assistance.
Publisher Copyright:
© 2020 by the authors.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - The objective of this study was to evaluate the biomaterial properties of nano-modified surface acupuncture needles and the effect of such needles on human pain perception by using pressure pain threshold (PPT) measurements. It is known that changing a material's surface nano-topography or nanostructure has strong effects on its physical, chemical, and biological surface properties. However, there is no information in the literature about the stimulation characteristics of acupuncture needles with nano-topography or nanostructured surfaces. Based on the knowledge on nanostructured surfaces, it may be possible to potentiate the effects of acupuncture needle stimulation. The pressure pain sensitivity of the masseter muscle in the orofacial region was studied in 21 healthy volunteers in two randomized, double-blinded sessions: an active session of manual acupuncture manipulation with nano-modified surface needles, and an inactive session of sham acupuncture stimulation to control for possible placebo effects. Three acupuncture points were selected from classical Chinese medicine literature: LI4 (Hegu) on the hand, ST6 (Jiache) on the lower masseter region, and ST7 (Xiaguan) on the upper masseter region. PPT measurements, perceived sensations, and pain from the acupuncture were recorded. The results showed discrete yet significant differences in PPT values between the active and inactive acupuncture treatments and significantly higher pain scores from active acupuncture stimulation than from sham acupuncture. These results indicate subtle but significant effects of acupuncture stimulation with nano-modified surface needles, compared to sham acupuncture in healthy participants.
AB - The objective of this study was to evaluate the biomaterial properties of nano-modified surface acupuncture needles and the effect of such needles on human pain perception by using pressure pain threshold (PPT) measurements. It is known that changing a material's surface nano-topography or nanostructure has strong effects on its physical, chemical, and biological surface properties. However, there is no information in the literature about the stimulation characteristics of acupuncture needles with nano-topography or nanostructured surfaces. Based on the knowledge on nanostructured surfaces, it may be possible to potentiate the effects of acupuncture needle stimulation. The pressure pain sensitivity of the masseter muscle in the orofacial region was studied in 21 healthy volunteers in two randomized, double-blinded sessions: an active session of manual acupuncture manipulation with nano-modified surface needles, and an inactive session of sham acupuncture stimulation to control for possible placebo effects. Three acupuncture points were selected from classical Chinese medicine literature: LI4 (Hegu) on the hand, ST6 (Jiache) on the lower masseter region, and ST7 (Xiaguan) on the upper masseter region. PPT measurements, perceived sensations, and pain from the acupuncture were recorded. The results showed discrete yet significant differences in PPT values between the active and inactive acupuncture treatments and significantly higher pain scores from active acupuncture stimulation than from sham acupuncture. These results indicate subtle but significant effects of acupuncture stimulation with nano-modified surface needles, compared to sham acupuncture in healthy participants.
KW - Acupuncture
KW - Nano-modified surface
KW - Orofacial pain
KW - Pressure pain threshold
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U2 - 10.3390/app10134578
DO - 10.3390/app10134578
M3 - Article
AN - SCOPUS:85087824305
SN - 2076-3417
VL - 10
JO - Applied Sciences (Switzerland)
JF - Applied Sciences (Switzerland)
IS - 13
M1 - 4578
ER -
