The polyphenolics in the aqueous extract of Psidium guajava kinetically reveal an inhibition model on LDL glycation

Kuan Chou Chen, Chao Ming Chuang, Li Yun Lin, Wen Ta Chiu, Hui Er Wang, Chiu Lan Hsieh, Tsui Min Tsai, Robert Y. Peng

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Guava [Psidium guajava L. (Myrtaceae)] budding leaf extract (PE) has shown tremendous bioactivities. Previously, we found seven major compounds in PE, i.e., gallic acid, catechin, epicatechin, rutin, quercetin, naringenin, and kaempferol. PE showed a potentially active antiglycative effect in an LDL (low density lipoprotein) mimic biomodel, which can be attributed to its large content of polyphenolics. The glycation and antiglycative reactions showed characteristic distinct four-phase kinetic patterns. In the presence of PE, the kinetic coefficients were 0.000438, 0.000060, 0.000, and -0.0001354 ABS-mL/mg-min, respectively, for phases 1 to 4. Computer simulation evidenced the dose-dependent inhibition model. Conclusively, PE contains a large amount of polyphenolics, whose antiglycative bioactivity fits the inhibition model.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalPharmaceutical Biology
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Psidium
Catechin
LDL Lipoproteins
Myrtaceae
Rutin
Gallic Acid
Quercetin
Computer Simulation
naringenin
kaempferol

Keywords

  • Antiglycation
  • LDL glycation
  • Psidium guajava L.

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine

Cite this

The polyphenolics in the aqueous extract of Psidium guajava kinetically reveal an inhibition model on LDL glycation. / Chen, Kuan Chou; Chuang, Chao Ming; Lin, Li Yun; Chiu, Wen Ta; Wang, Hui Er; Hsieh, Chiu Lan; Tsai, Tsui Min; Peng, Robert Y.

In: Pharmaceutical Biology, Vol. 48, No. 1, 01.2010, p. 23-31.

Research output: Contribution to journalArticle

Chen, Kuan Chou ; Chuang, Chao Ming ; Lin, Li Yun ; Chiu, Wen Ta ; Wang, Hui Er ; Hsieh, Chiu Lan ; Tsai, Tsui Min ; Peng, Robert Y. / The polyphenolics in the aqueous extract of Psidium guajava kinetically reveal an inhibition model on LDL glycation. In: Pharmaceutical Biology. 2010 ; Vol. 48, No. 1. pp. 23-31.
@article{8f877ce883dd46dd863edd19fbc54fc9,
title = "The polyphenolics in the aqueous extract of Psidium guajava kinetically reveal an inhibition model on LDL glycation",
abstract = "Guava [Psidium guajava L. (Myrtaceae)] budding leaf extract (PE) has shown tremendous bioactivities. Previously, we found seven major compounds in PE, i.e., gallic acid, catechin, epicatechin, rutin, quercetin, naringenin, and kaempferol. PE showed a potentially active antiglycative effect in an LDL (low density lipoprotein) mimic biomodel, which can be attributed to its large content of polyphenolics. The glycation and antiglycative reactions showed characteristic distinct four-phase kinetic patterns. In the presence of PE, the kinetic coefficients were 0.000438, 0.000060, 0.000, and -0.0001354 ABS-mL/mg-min, respectively, for phases 1 to 4. Computer simulation evidenced the dose-dependent inhibition model. Conclusively, PE contains a large amount of polyphenolics, whose antiglycative bioactivity fits the inhibition model.",
keywords = "Antiglycation, LDL glycation, Psidium guajava L.",
author = "Chen, {Kuan Chou} and Chuang, {Chao Ming} and Lin, {Li Yun} and Chiu, {Wen Ta} and Wang, {Hui Er} and Hsieh, {Chiu Lan} and Tsai, {Tsui Min} and Peng, {Robert Y.}",
year = "2010",
month = "1",
doi = "10.3109/13880200903029365",
language = "English",
volume = "48",
pages = "23--31",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - The polyphenolics in the aqueous extract of Psidium guajava kinetically reveal an inhibition model on LDL glycation

AU - Chen, Kuan Chou

AU - Chuang, Chao Ming

AU - Lin, Li Yun

AU - Chiu, Wen Ta

AU - Wang, Hui Er

AU - Hsieh, Chiu Lan

AU - Tsai, Tsui Min

AU - Peng, Robert Y.

PY - 2010/1

Y1 - 2010/1

N2 - Guava [Psidium guajava L. (Myrtaceae)] budding leaf extract (PE) has shown tremendous bioactivities. Previously, we found seven major compounds in PE, i.e., gallic acid, catechin, epicatechin, rutin, quercetin, naringenin, and kaempferol. PE showed a potentially active antiglycative effect in an LDL (low density lipoprotein) mimic biomodel, which can be attributed to its large content of polyphenolics. The glycation and antiglycative reactions showed characteristic distinct four-phase kinetic patterns. In the presence of PE, the kinetic coefficients were 0.000438, 0.000060, 0.000, and -0.0001354 ABS-mL/mg-min, respectively, for phases 1 to 4. Computer simulation evidenced the dose-dependent inhibition model. Conclusively, PE contains a large amount of polyphenolics, whose antiglycative bioactivity fits the inhibition model.

AB - Guava [Psidium guajava L. (Myrtaceae)] budding leaf extract (PE) has shown tremendous bioactivities. Previously, we found seven major compounds in PE, i.e., gallic acid, catechin, epicatechin, rutin, quercetin, naringenin, and kaempferol. PE showed a potentially active antiglycative effect in an LDL (low density lipoprotein) mimic biomodel, which can be attributed to its large content of polyphenolics. The glycation and antiglycative reactions showed characteristic distinct four-phase kinetic patterns. In the presence of PE, the kinetic coefficients were 0.000438, 0.000060, 0.000, and -0.0001354 ABS-mL/mg-min, respectively, for phases 1 to 4. Computer simulation evidenced the dose-dependent inhibition model. Conclusively, PE contains a large amount of polyphenolics, whose antiglycative bioactivity fits the inhibition model.

KW - Antiglycation

KW - LDL glycation

KW - Psidium guajava L.

UR - http://www.scopus.com/inward/record.url?scp=73949141756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73949141756&partnerID=8YFLogxK

U2 - 10.3109/13880200903029365

DO - 10.3109/13880200903029365

M3 - Article

C2 - 20645752

AN - SCOPUS:73949141756

VL - 48

SP - 23

EP - 31

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

IS - 1

ER -