The octamers d(CGCGCGCG) and d(CGCATGCG) both crystallize as Z‐DNA in the same hexagonal lattice

Satoshi Fujii, Andrew H.‐J Wang, Gary J. Quigley, Henk Westerink, Gijs Van Der Marel, Jacques H. Van Boom, Alexander Rich

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Both (dC‐dG)4 and d(CGCATGCG) crystallize in hexagonal lattices and their three‐dimensional structure has been solved by x‐ray diffraction analysis. Both molecules are found to form Z‐DNA, although the fine details of the structure cannot be visualized due to the statistical disordering of the molecules along the c‐axis, which is brought about by the symmetry constraints of the space group. This represents the first time in which the unmodified dinucleotide sequences CpAp and TpGp have been found to form Z‐DNA in a crystalline lattice.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalBiopolymers
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

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