The Obesity-Mortality Paradox in Patients With Heart Failure in Taiwan and a Collaborative Meta-Analysis for East Asian Patients

Gen Min Lin, Yi Hwei Li, Wei Hsian Yin, Yen Wen Wu, Pao Hsien Chu, Chih Cheng Wu, Chih Hsin Hsu, Ming Shien Wen, Wen Chol Voon, Chun Chieh Wang, San Jou Yeh, Wei Shiang Lin, Kuei Chuan Chan, Heng Chia Chang, Kuan Cheng Chang, Zhih Cherng Chen, Shyh Ming Chen, Pao Hsien Chu, Chih Hsin Hsu, Jin Long HuangJen yuan Kuo, Jiunn-Lee Lin, Wei Shiang Lin, Guang Yuan Mar, Kou Gi Shyu, Shih Hsien Sung, Wei Kung Tseng, Wen Chol Voon, Ji Hung Wang, Ming Shien Wen, Chih Cheng Wu, Ning I. Yang, Wei Hsian Yin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A global heart failure (HF) registry suggested that the inverse association between body mass index (BMI) and all-cause mortality differed by race, particularly stronger in Japanese patients at 1-year follow-up. Whether this finding was consistent across all East Asian populations was unknown. In a multicenter prospective study in Taiwan, we enrolled 1,301 patients hospitalized for systolic HF from 2013 to 2014 and followed up the mortality after their discharge for a median of 1-year period. Cox proportional hazard regression analyses were used to assess the association of BMI with all-cause mortality. The results showed that BMI was inversely associated with all-cause mortality (hazard ratio and 95% CI per 5-kg/m2 increase: 0.75 [0.62 to 0.91]) after adjusting for demographics, traditional risk factors, HF severity, and medications at discharge. Subsequently, we sought previous studies regarding the BMI association with mortality for East Asian patients with HF from Medline, and a random-effect meta-analysis was performed by the inverse variance method. The meta-analysis including 7 previous eligible studies (3 for the Chinese and 4 for the Japanese cohorts) and the present one showed similar results that BMI was inversely associated with all-cause mortality (hazard ratio 0.65 [0.58 to 0.73], I2 = 37%). In conclusion, our study in Taiwan and a collaborative meta-analysis confirmed a strong inverse BMI-mortality association consistently among East Asian patients with HF.

Original languageEnglish
Pages (from-to)1011-1018
Number of pages8
JournalAmerican Journal of Cardiology
Volume118
Issue number7
DOIs
Publication statusPublished - Oct 1 2016
Externally publishedYes

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Taiwan
Meta-Analysis
Heart Failure
Obesity
Body Mass Index
Mortality
Systolic Heart Failure
Multicenter Studies
Registries
Regression Analysis
Demography
Prospective Studies
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The Obesity-Mortality Paradox in Patients With Heart Failure in Taiwan and a Collaborative Meta-Analysis for East Asian Patients. / Lin, Gen Min; Li, Yi Hwei; Yin, Wei Hsian; Wu, Yen Wen; Chu, Pao Hsien; Wu, Chih Cheng; Hsu, Chih Hsin; Wen, Ming Shien; Voon, Wen Chol; Wang, Chun Chieh; Yeh, San Jou; Lin, Wei Shiang; Chan, Kuei Chuan; Chang, Heng Chia; Chang, Kuan Cheng; Chen, Zhih Cherng; Chen, Shyh Ming; Chu, Pao Hsien; Hsu, Chih Hsin; Huang, Jin Long; Kuo, Jen yuan; Lin, Jiunn-Lee; Lin, Wei Shiang; Mar, Guang Yuan; Shyu, Kou Gi; Sung, Shih Hsien; Tseng, Wei Kung; Voon, Wen Chol; Wang, Ji Hung; Wen, Ming Shien; Wu, Chih Cheng; Yang, Ning I.; Yin, Wei Hsian.

In: American Journal of Cardiology, Vol. 118, No. 7, 01.10.2016, p. 1011-1018.

Research output: Contribution to journalArticle

Lin, GM, Li, YH, Yin, WH, Wu, YW, Chu, PH, Wu, CC, Hsu, CH, Wen, MS, Voon, WC, Wang, CC, Yeh, SJ, Lin, WS, Chan, KC, Chang, HC, Chang, KC, Chen, ZC, Chen, SM, Chu, PH, Hsu, CH, Huang, JL, Kuo, JY, Lin, J-L, Lin, WS, Mar, GY, Shyu, KG, Sung, SH, Tseng, WK, Voon, WC, Wang, JH, Wen, MS, Wu, CC, Yang, NI & Yin, WH 2016, 'The Obesity-Mortality Paradox in Patients With Heart Failure in Taiwan and a Collaborative Meta-Analysis for East Asian Patients', American Journal of Cardiology, vol. 118, no. 7, pp. 1011-1018. https://doi.org/10.1016/j.amjcard.2016.06.056
Lin, Gen Min ; Li, Yi Hwei ; Yin, Wei Hsian ; Wu, Yen Wen ; Chu, Pao Hsien ; Wu, Chih Cheng ; Hsu, Chih Hsin ; Wen, Ming Shien ; Voon, Wen Chol ; Wang, Chun Chieh ; Yeh, San Jou ; Lin, Wei Shiang ; Chan, Kuei Chuan ; Chang, Heng Chia ; Chang, Kuan Cheng ; Chen, Zhih Cherng ; Chen, Shyh Ming ; Chu, Pao Hsien ; Hsu, Chih Hsin ; Huang, Jin Long ; Kuo, Jen yuan ; Lin, Jiunn-Lee ; Lin, Wei Shiang ; Mar, Guang Yuan ; Shyu, Kou Gi ; Sung, Shih Hsien ; Tseng, Wei Kung ; Voon, Wen Chol ; Wang, Ji Hung ; Wen, Ming Shien ; Wu, Chih Cheng ; Yang, Ning I. ; Yin, Wei Hsian. / The Obesity-Mortality Paradox in Patients With Heart Failure in Taiwan and a Collaborative Meta-Analysis for East Asian Patients. In: American Journal of Cardiology. 2016 ; Vol. 118, No. 7. pp. 1011-1018.
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AU - Yin, Wei Hsian

AU - Wu, Yen Wen

AU - Chu, Pao Hsien

AU - Wu, Chih Cheng

AU - Hsu, Chih Hsin

AU - Wen, Ming Shien

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AU - Sung, Shih Hsien

AU - Tseng, Wei Kung

AU - Voon, Wen Chol

AU - Wang, Ji Hung

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