The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

Cheng Kuei Chang, Fu Yu Chueh, Ming Tsuen Hsieh, Mao Tsun Lin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalNeuroscience Letters
Volume267
Issue number2
DOIs
Publication statusPublished - May 28 1999
Externally publishedYes

Keywords

  • Brain
  • Cerebral ischemia
  • Heatstroke
  • Monoamines
  • Neuronal injury
  • Tetrahydroxypalmatine

ASJC Scopus subject areas

  • Neuroscience(all)

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