The multifaceted role of mesenchymal stem cells in cancer

Michael Timaner, Kelvin K. Tsai, Yuval Shaked

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.

Original languageEnglish
JournalSeminars in Cancer Biology
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Mesenchymal Stromal Cells
Neoplasms
Multipotent Stem Cells
Epithelial-Mesenchymal Transition
Mesoderm
Immunosuppressive Agents
Chondrocytes
Cell- and Tissue-Based Therapy
Osteoblasts
Adipocytes
Immunosuppression
Muscle Cells
Neoplasm Metastasis
Therapeutics

Keywords

  • Angiogenesis
  • Immunosuppression
  • Mesenchymal stem cells
  • Metastasis
  • Resistance

ASJC Scopus subject areas

  • Cancer Research

Cite this

The multifaceted role of mesenchymal stem cells in cancer. / Timaner, Michael; Tsai, Kelvin K.; Shaked, Yuval.

In: Seminars in Cancer Biology, 01.01.2019.

Research output: Contribution to journalReview article

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