The multifaceted role of mesenchymal stem cells in cancer

Michael Timaner; Kelvin K. Tsai; Yuval Shaked

doi:10.1016/j.semcancer.2019.06.003

The multifaceted role of mesenchymal stem cells in cancer

Michael Timaner, Kelvin K. Tsai, Yuval Shaked

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.

Original language	English
Journal	Seminars in Cancer Biology
DOIs	https://doi.org/10.1016/j.semcancer.2019.06.003
Publication status	Accepted/In press - Jan 1 2019

Keywords

Angiogenesis
Immunosuppression
Mesenchymal stem cells
Metastasis
Resistance

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1016/j.semcancer.2019.06.003

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abstract = "Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.",

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AU - Tsai, Kelvin K.

AU - Shaked, Yuval

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N2 - Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.

AB - Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.

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KW - Immunosuppression

KW - Mesenchymal stem cells

KW - Metastasis

KW - Resistance

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AN - SCOPUS:85067352621

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

SN - 1044-579X

ER -

The multifaceted role of mesenchymal stem cells in cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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