TY - JOUR
T1 - The multifaceted role of mesenchymal stem cells in cancer
AU - Timaner, Michael
AU - Tsai, Kelvin K.
AU - Shaked, Yuval
PY - 2020/2
Y1 - 2020/2
N2 - Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.
AB - Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.
KW - Angiogenesis
KW - Immunosuppression
KW - Mesenchymal stem cells
KW - Metastasis
KW - Resistance
UR - http://www.scopus.com/inward/record.url?scp=85067352621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067352621&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2019.06.003
DO - 10.1016/j.semcancer.2019.06.003
M3 - Review article
AN - SCOPUS:85067352621
VL - 60
SP - 225
EP - 237
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
SN - 1044-579X
ER -
