The multifaceted link between inflammation and human diseases

Peramaiyan Rajendran, Ya Fang Chen, Yu Feng Chen, Li Chin Chung, Shanmugam Tamilselvi, Chia Yao Shen, Cecilia Hsuan Day, Ray Jade Chen, Vijaya P. Viswanadha, Wei Wen Kuo, Chih Yang Huang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Increasing reports on epidemiological, diagnostic, and clinical studies suggest that dysfunction of the inflammatory reaction results in chronic illnesses such as cancer, arthritis, arteriosclerosis, neurological disorders, liver diseases, and renal disorders. Chronic inflammation might progress if injurious agent persists; however, more typically than not, the response is chronic from the start. Distinct to most changes in acute inflammation, chronic inflammation is characterized by the infiltration of damaged tissue by mononuclear cells like macrophages, lymphocytes, and plasma cells, in addition to tissue destruction and attempts to repair. Phagocytes are the key players in the chronic inflammatory response. However, the important drawback is the activation of pathological phagocytes, which might result from continued tissue damage and lead to harmful diseases. The longer the inflammation persists, the greater the chance for the establishment of human diseases. The aim of this review was to focus on advances in the understanding of chronic inflammation and to summarize the impact and involvement of inflammatory agents in certain human diseases.

Original languageEnglish
JournalJournal of Cellular Physiology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Inflammation
Tissue
Phagocytes
Lymphocytes
Macrophages
Infiltration
Liver
Arteriosclerosis
Plasma Cells
Nervous System Diseases
Repair
Chemical activation
Arthritis
Liver Diseases
Epidemiologic Studies
Plasmas
Chronic Disease
Kidney
Neoplasms

Keywords

  • Arthritis
  • Atherosclerosis
  • Cancer
  • Inflammation
  • Neurological disorders

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Rajendran, P., Chen, Y. F., Chen, Y. F., Chung, L. C., Tamilselvi, S., Shen, C. Y., ... Huang, C. Y. (Accepted/In press). The multifaceted link between inflammation and human diseases. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.26479

The multifaceted link between inflammation and human diseases. / Rajendran, Peramaiyan; Chen, Ya Fang; Chen, Yu Feng; Chung, Li Chin; Tamilselvi, Shanmugam; Shen, Chia Yao; Day, Cecilia Hsuan; Chen, Ray Jade; Viswanadha, Vijaya P.; Kuo, Wei Wen; Huang, Chih Yang.

In: Journal of Cellular Physiology, 01.01.2018.

Research output: Contribution to journalArticle

Rajendran, P, Chen, YF, Chen, YF, Chung, LC, Tamilselvi, S, Shen, CY, Day, CH, Chen, RJ, Viswanadha, VP, Kuo, WW & Huang, CY 2018, 'The multifaceted link between inflammation and human diseases', Journal of Cellular Physiology. https://doi.org/10.1002/jcp.26479
Rajendran P, Chen YF, Chen YF, Chung LC, Tamilselvi S, Shen CY et al. The multifaceted link between inflammation and human diseases. Journal of Cellular Physiology. 2018 Jan 1. https://doi.org/10.1002/jcp.26479
Rajendran, Peramaiyan ; Chen, Ya Fang ; Chen, Yu Feng ; Chung, Li Chin ; Tamilselvi, Shanmugam ; Shen, Chia Yao ; Day, Cecilia Hsuan ; Chen, Ray Jade ; Viswanadha, Vijaya P. ; Kuo, Wei Wen ; Huang, Chih Yang. / The multifaceted link between inflammation and human diseases. In: Journal of Cellular Physiology. 2018.
@article{377158758aea49b4ace2cf8a82ca3c55,
title = "The multifaceted link between inflammation and human diseases",
abstract = "Increasing reports on epidemiological, diagnostic, and clinical studies suggest that dysfunction of the inflammatory reaction results in chronic illnesses such as cancer, arthritis, arteriosclerosis, neurological disorders, liver diseases, and renal disorders. Chronic inflammation might progress if injurious agent persists; however, more typically than not, the response is chronic from the start. Distinct to most changes in acute inflammation, chronic inflammation is characterized by the infiltration of damaged tissue by mononuclear cells like macrophages, lymphocytes, and plasma cells, in addition to tissue destruction and attempts to repair. Phagocytes are the key players in the chronic inflammatory response. However, the important drawback is the activation of pathological phagocytes, which might result from continued tissue damage and lead to harmful diseases. The longer the inflammation persists, the greater the chance for the establishment of human diseases. The aim of this review was to focus on advances in the understanding of chronic inflammation and to summarize the impact and involvement of inflammatory agents in certain human diseases.",
keywords = "Arthritis, Atherosclerosis, Cancer, Inflammation, Neurological disorders",
author = "Peramaiyan Rajendran and Chen, {Ya Fang} and Chen, {Yu Feng} and Chung, {Li Chin} and Shanmugam Tamilselvi and Shen, {Chia Yao} and Day, {Cecilia Hsuan} and Chen, {Ray Jade} and Viswanadha, {Vijaya P.} and Kuo, {Wei Wen} and Huang, {Chih Yang}",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/jcp.26479",
language = "English",
journal = "Journal of Cellular Physiology",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - The multifaceted link between inflammation and human diseases

AU - Rajendran, Peramaiyan

AU - Chen, Ya Fang

AU - Chen, Yu Feng

AU - Chung, Li Chin

AU - Tamilselvi, Shanmugam

AU - Shen, Chia Yao

AU - Day, Cecilia Hsuan

AU - Chen, Ray Jade

AU - Viswanadha, Vijaya P.

AU - Kuo, Wei Wen

AU - Huang, Chih Yang

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Increasing reports on epidemiological, diagnostic, and clinical studies suggest that dysfunction of the inflammatory reaction results in chronic illnesses such as cancer, arthritis, arteriosclerosis, neurological disorders, liver diseases, and renal disorders. Chronic inflammation might progress if injurious agent persists; however, more typically than not, the response is chronic from the start. Distinct to most changes in acute inflammation, chronic inflammation is characterized by the infiltration of damaged tissue by mononuclear cells like macrophages, lymphocytes, and plasma cells, in addition to tissue destruction and attempts to repair. Phagocytes are the key players in the chronic inflammatory response. However, the important drawback is the activation of pathological phagocytes, which might result from continued tissue damage and lead to harmful diseases. The longer the inflammation persists, the greater the chance for the establishment of human diseases. The aim of this review was to focus on advances in the understanding of chronic inflammation and to summarize the impact and involvement of inflammatory agents in certain human diseases.

AB - Increasing reports on epidemiological, diagnostic, and clinical studies suggest that dysfunction of the inflammatory reaction results in chronic illnesses such as cancer, arthritis, arteriosclerosis, neurological disorders, liver diseases, and renal disorders. Chronic inflammation might progress if injurious agent persists; however, more typically than not, the response is chronic from the start. Distinct to most changes in acute inflammation, chronic inflammation is characterized by the infiltration of damaged tissue by mononuclear cells like macrophages, lymphocytes, and plasma cells, in addition to tissue destruction and attempts to repair. Phagocytes are the key players in the chronic inflammatory response. However, the important drawback is the activation of pathological phagocytes, which might result from continued tissue damage and lead to harmful diseases. The longer the inflammation persists, the greater the chance for the establishment of human diseases. The aim of this review was to focus on advances in the understanding of chronic inflammation and to summarize the impact and involvement of inflammatory agents in certain human diseases.

KW - Arthritis

KW - Atherosclerosis

KW - Cancer

KW - Inflammation

KW - Neurological disorders

UR - http://www.scopus.com/inward/record.url?scp=85043387156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043387156&partnerID=8YFLogxK

U2 - 10.1002/jcp.26479

DO - 10.1002/jcp.26479

M3 - Article

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

SN - 0021-9541

ER -