The mir-423-5p/mmp-2 axis regulates the nerve growth factor-induced promotion of chondrosarcoma metastasis

Huey En Tzeng, Syuan Ling Lin, Louis Anoop Thadevoos, Chih Yuan Ko, Ju Fang Liu, Yu Wen Huang, Chih Yang Lin, Yi Chin Fong, Chih Hsin Tang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propen-sity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although the effects of NGF in a chon-drosarcoma are not confirmed. Here, we found that the levels of NGF and matrix metalloproteinase-2 (MMP-2) correlated with the tumor stage in patients with a chondrosarcoma. NGF facilitated the MMP-2-dependent cellular migration in human chondrosarcoma JJ012 cells while the overexpres-sion of NGF enhanced the lung metastasis in a mouse model of a chondrosarcoma. NGF promoted the MMP-2 synthesis and cell migration by inhibiting miR-423-5p expression through the FAK and c-Src signaling cascades. NGF appears to be a worthwhile therapeutic target in the treatment of a metastatic chondrosarcoma.

Original languageEnglish
Article number3347
JournalCancers
Volume13
Issue number13
DOIs
Publication statusPublished - Jul 1 2021

Keywords

  • Chondrosarcoma
  • Metastasis
  • MiR-423-5p
  • MMP-2
  • NGF

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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