Superficial basal cell carcinoma is a distinct variant of basal cell carcinoma not only histological- ly but also biologically. Its indolent growth and occasionally misleading clinical presentation can sometimes pose a diagnostic challenge to clinicians. In this report, we describe three lesions of super-ficial basal cell carcinoma in two Taiwanese patients.Their clinical appearances were drastically dif-ferent from each other. The histopathology of the three lesions varied in the aspects of the tumor islands and the components of peritumoral stroma. The diverse clinicopathological pictures of superfi-cial BCC demonstrate the complex and conditioned pathogenesis of the tumor. In addition, immuno-histochemical studies with Ki-67 and bc1-2were performed on our cases and two cases of trichoep-ithelioma as well. Ki-67 is epressed in a random fashion within the tumor nests of superficial BCC, while trichoepithelioma is barely positive with Ki-67. Diffuse staining of bc1-2 is seen on the tumor nests of superficial BCC. In contrast, only the periphery of the tumor nests is bc1-2 positive in tri-choepithelioma. The differential immunostaining profile of the two lesions reflects their respective biological behaviors and may be of value in separating the two conditions in certain problematic cases.
|Number of pages||9|
|Publication status||Published - 2002|
- Superficial basal cell carcinoma
Wang, K-H., Fang, C-L., Lai, C-C., & Lee, W-R. (2002). The Many Faces of Superficial Basal Cell Carcinoma -Clinicopathological and Immunohistochemical Studies of Three Different Lesions-. Dermatologica Sinica, 20(4), 335-343. http://www.AiritiLibrary.com/Publication/Index/10278117-200212-20-4-335-343-a