The many blades of the β-propeller proteins: Conserved but versatile

Cammy K.M. Chen, Nei Li Chan, Andrew H.J. Wang

Research output: Contribution to journalReview articlepeer-review

117 Citations (Scopus)

Abstract

The β-propeller is a highly symmetrical structure with 4-10 repeats of a four-stranded antiparallel β-sheet motif. Although β-propeller proteins with different blade numbers all adopt disc-like shapes, they are involved in a diverse set of functions, and defects in this family of proteins have been associated with human diseases. However, it has remained ambiguous how variations in blade number could alter the function of β-propellers. In addition to the regularly arranged β-propeller topology, a recently discovered β-pinwheel propeller has been found. Here, we review the structural and functional diversity of β-propeller proteins, including β-pinwheels, as well as recent advances in the typical and atypical propeller structures.

Original languageEnglish
Pages (from-to)553-561
Number of pages9
JournalTrends in Biochemical Sciences
Volume36
Issue number10
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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